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SERPINA3

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For Research Use Only. Not For Clinical Use.


Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
SERPINA3
Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Metabolic proteins, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Fibroblasts, Exocrine glandular cells, Ductal cells, Pancreatic endocrine cells, Late spermatids)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (Hep G2)

Interaction

Interacts with DNAJC1.

Molecular function

Protease inhibitor, Serine protease inhibitor

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