Rabbit Anti-SERPINA3 Recombinant Antibody (clone R03-4U6) (CAT#: VS3-XY3499)
This product is a recombinant rabbit antibody binding to SERPINA3 (Serpin family A member 3), which can inhibit neutrophil cathepsin G and mast cell chymase. The antibody specifically recognizes the epitope of human SERPINA3. It has been reported for use in Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Immunocytochemistry or Immunofluorescence.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human cervix, uterine
(Immunohistochemical staining of human cervix, uterine shows moderate cytoplasmic staining in glandular cells and secreted positivity.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16647/166236_B_7_3_selected.jpg
(Immunohistochemical staining of human cervix, uterine shows moderate cytoplasmic staining in glandular cells and secreted positivity.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16647/166236_B_7_3_selected.jpg
Figure 2 Liver
(Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2560/166232_A_7_4.jpg
(Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2560/166232_A_7_4.jpg
Figure 3 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2560/166232_A_4_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2560/166232_A_4_6.jpg
Figure 4 Cervix
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2560/166232_B_7_3.jpg
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2560/166232_B_7_3.jpg
Figure 5 RNA cell line category: Cell line enriched (Hep G2)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196136-SERPINA3
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196136-SERPINA3
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human SERPINA3
- Species Reactivity
- Human
- Clone
- R03-4U6
- Applications
- WB, IHC-P, ICC, IF, IP
- Related Disease
- Alpha-1-Antitrypsin Deficiency; Malignant Fibrous Histiocytoma
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
Target
- Alternative Names
- ACT; AACT; GIG24; GIG25
- Gene ID
- 12
- UniProt ID
- P01011
- Long Name
- Serpin family A member 3
- Cellular Localization
- Secreted
- Post Translation Modifications
- N- and O-glycosylated. (P01011-AACT_HUMAN)
Glycosylation at Asn33, Asn93, Asn106, Asn127, Asn186, Asn271, and Thr347 (NX_P01011 [NX_P01011-1])
Modification sites at PhosphoSitePlus (P01011)
Glycosylation from GlyConnect AACT_HUMAN (19)
Glycosylation from GlyGen (P01011) 12 sites, 85 N-linked glycans (6 sites), 4 O-linked glycans (6 sites)
- Protein Refseq
- NP_001371601.1; NP_001076.2
- Function
- Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "SERPINA3"
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Please select product type
IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0507MZ | Recombinant Mouse Anti-Human SERPINA3 Antibody (clone 71A1) | IHC-P, WB, sELISA | Mouse antibody |
| MRO-0060-CN | Recombinant Rabbit Anti-SERPINA3 Monoclonal Antibody (JM83-29) | WB, IHC, IP | Rabbit IgG |
| VS3-WK132 | Mouse Anti-SERPINA3 Recombinant Antibody (clone G3-C11) | WB, IHC, FC | Mouse IgG1 |
| VS3-XY1411 | Mouse Anti-SERPINA3 Recombinant Antibody (clone 1B3A2) | ELISA, WB, IHC, FC | Mouse IgG1 |
| VS3-XY1412 | Mouse Anti-SERPINA3 Recombinant Antibody (clone 8G12C1) | ELISA, WB, FC, IHC | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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