Rabbit Anti-SERPINA3 Recombinant Antibody (clone R03-4U6)
CAT#: VS3-XY3499
This product is a recombinant rabbit antibody binding to SERPINA3 (Serpin family A member 3), which can inhibit neutrophil cathepsin G and mast cell chymase. The antibody specifically recognizes the epitope of human SERPINA3. It has been reported for use in Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Immunocytochemistry or Immunofluorescence.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human cervix, uterine
Immunohistochemical staining of human cervix, uterine shows moderate cytoplasmic staining in glandular cells and secreted positivity.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16647/166236_B_7_3_selected.jpg
Normal Tissue
Figure 2 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2560/166232_A_7_4.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2560/166232_A_4_6.jpg
Normal Tissue
Figure 4 Cervix
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2560/166232_B_7_3.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (Hep G2)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196136-SERPINA3
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human SERPINA3
- Species Reactivity
- Human
- Clone
- R03-4U6
- Applications
- WB, IHC-P, ICC, IF, IP
- Related Disease
- Alpha-1-Antitrypsin Deficiency; Malignant Fibrous Histiocytoma
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
Target
- Alternative Names
- ACT; AACT; GIG24; GIG25
- Gene ID
- 12
- UniProt ID
- P01011
- Long Name
- Serpin family A member 3
- Cellular Localization
- Secreted
- Post Translation Modifications
- N- and O-glycosylated. (P01011-AACT_HUMAN)
Glycosylation at Asn33, Asn93, Asn106, Asn127, Asn186, Asn271, and Thr347 (NX_P01011 [NX_P01011-1])
Modification sites at PhosphoSitePlus (P01011)
Glycosylation from GlyConnect AACT_HUMAN (19)
Glycosylation from GlyGen (P01011) 12 sites, 85 N-linked glycans (6 sites), 4 O-linked glycans (6 sites)
- Protein Refseq
- NP_001371601.1; NP_001076.2
- Function
- Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "SERPINA3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1778z | Mouse Anti-SERPINA3 Recombinant Antibody (clone 28F4) | WB, FC, ICC, IHC | Mouse IgG1 |
| MOB-0507MZ | Recombinant Mouse Anti-Human SERPINA3 Antibody (clone 71A1) | IHC-P, WB, sELISA | Mouse antibody |
| VS3-WK132 | Mouse Anti-SERPINA3 Recombinant Antibody (clone G3-C11) | WB, IHC, FC | Mouse IgG1 |
| VS3-XY1411 | Mouse Anti-SERPINA3 Recombinant Antibody (clone 1B3A2) | ELISA, WB, IHC, FC | Mouse IgG1 |
| VS7-0425-WR845 | Mouse Anti-SERPINA3 Recombinant Antibody (clone 5G3C11) | WB, IHC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3214 | Hi-Affi™ Recombinant Rabbit Anti-SERPINA3 Monoclonal Antibody (DS3214AB) | WB, IP | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6472 | Anti-SERPINA3 Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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