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For Research Use Only. Not For Clinical Use.
Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins
Secreted
Cell type enhanced (Cholangiocytes, Glandular and luminal cells, Late spermatids, Hepatocytes, Endometrial ciliated cells, Peritubular cells)
Not detected in immune cells
Cell line enriched (Hep G2)
Forms protease inhibiting heterodimers in extracellular body fluids with serine proteases such as activated protein C/coagulation factor V/F5, acrosin/ACR, chymotrypsinogen B/CTRB1, prothrombin/F2, factor Xa/F10, factor XI/F11, kallikrein/KLKB1, tissue kallikrein, trypsin/PRSS1, prostate specific antigen/KLK3, tissue plasminogen activator/PLAT and urinary plasminogen activator/PLAU. Forms membrane-anchored serine proteases inhibiting heterodimers with TMPRSS7 and TMPRSS11E. Interacts with SEMG2.
Heparin-binding, Protease inhibitor, Serine protease inhibitor