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SLPI

The fully human monoclonal antibodies against secretory leukocyte protease inhibitor (SLPI) expressed in respiratory epithelium and also in a variety of cancers including lung, breast, oropharyngeal, bladder, ovarian, endometrial and colorectal. SLPI expression has been correlated with tumor progression.
Protein class

Cancer-related genes, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Club cells, Basal respiratory cells, Respiratory ciliated cells, Alveolar cells type 2)

Immune cell specificity

Immune cell enriched (neutrophil)

Cell line specificity

Cell line enhanced (EFO-21, hTCEpi, OE19, SiHa, THP-1)

Interaction

Interacts with GRN; interaction protects progranulin from proteolysis.

Molecular function

Antibiotic, Antimicrobial, Protease inhibitor, Serine protease inhibitor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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