+ Filter
Loading...
SNX5
Anti-SNX5 Recombinant Antibody Products
- PE-B*44:03/Human SNX5 (EEPTVIKKY) MHC Tetramer (MHC-LC1247)
-
- Class: Class I
- Antigen: SNX5
- Antigen Species: Human
- Peptide: EEPTVIKKY
- Conjugate: PE
Compare
- APC-B*44:03/Human SNX5 (EEPTVIKKY) MHC Tetramer (MHC-LC1248)
-
- Class: Class I
- Antigen: SNX5
- Antigen Species: Human
- Peptide: EEPTVIKKY
- Conjugate: APC
Compare
- BV421-B*44:03/Human SNX5 (EEPTVIKKY) MHC Tetramer (MHC-LC1249)
-
- Class: Class I
- Antigen: SNX5
- Antigen Species: Human
- Peptide: EEPTVIKKY
- Conjugate: BV421
Compare
- Anti-SNX5 Immunohistochemistry Kit (VS-0325-XY2139)
-
- Species Reactivity: Human, Mouse, Rat
- Target: SNX5
- Application: IHC
Compare
More Infomation
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
More Infomation
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
For Research Use Only. Not For Clinical Use.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Proximal tubular cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Hep G2)
Interaction
Forms heterodimers with BAR domain-containing sorting nexins SNX1 and SNX2; does not homodimerize (PubMed:23085988). The heterodimers are proposed to self-assemble into helical arrays on the membrane to stabilize and expand local membrane curvature underlying endosomal tubule formation. Thought to be a component of the originally described retromer complex (also called SNX-BAR retromer) which is a pentamer containing the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS), and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity (Probable). Interacts with SNX1, SNX2, VPS26A, VPS29, VPS35, DCTN1, DOCK1, MIB1, PIP5K1C isoform 3. Interacts with HGS; increased by PIP5K1C isoform 3 kinase activity and by PtdIns(3P) and/or PtdIns(3,4)P2 (PubMed:16857196, PubMed:16968745, PubMed:19619496, PubMed:23085988, PubMed:18596235, PubMed:23602387, PubMed:24610942). (Microbial infection) Interacts with human cytomegalovirus proteins UL35 and UL35A; these interactions inhibit the ability of USP7 to form nuclear bodies.
More Types Infomation