Cancer-related genes, Disease related genes, Human disease related genes
Intracellular
Cell type enhanced (Early spermatids, Late spermatids)
Low immune cell specificity
Low cell line specificity
May form homodimers (PubMed:10564661). Part of a DNA-bound corepressor complex containing SAP18, GLI1 and SIN3 (By similarity). Part of a complex containing CTNNB1 (By similarity). Binds BTRC, GLI2, GLI3, SAP18 and STK36 (PubMed:10564661, 10806483). Binds both free and DNA-bound GLI1 (PubMed:10559945, 15367681, 24217340, 24311597, 28965847). Interacts with KIF7 (By similarity). Interacts with GLI3FL and this interaction regulates the formation of either repressor or activator forms of GLI3 (PubMed:24311597, 28965847). Its association with GLI3FL is regulated by Hh signaling and dissociation of the SUFU-GLI3 interaction requires the presence of the ciliary motor KIF3A (PubMed:24311597, 28965847). Interacts with ULK3; inactivating the protein kinase activity of ULK3 (PubMed:20643644). Interacts with RAB23 (PubMed:22365972).
Developmental protein
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For Research Use Only. Not For Clinical Use.