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SUMO4

This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.
Protein class

Disease related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Cardiomyocytes, Glandular and luminal cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (HeLa)

Interaction

Interacts with SAE2. Covalently attached to a number of proteins (Probable).

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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