TFEB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IF, IP
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- Recombinant Mouse Anti-TFEB Antibody (VS-0923-FY144) (VS-0923-FY144)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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- Anti-TFEB Immunohistochemistry Kit (VS-0325-XY2274)
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- Species Reactivity: Human, Mouse, Rat
- Target: TFEB
- Application: IHC
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- Anti-Mouse TFEB Immunohistochemistry Kit (VS-0525-XY7191)
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- Species Reactivity: Human, Mouse, Rat
- Target: TFEB
- Application: IHC
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- Anti-Human TFEB Immunohistochemistry Kit (VS-0525-XY7190)
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- Species Reactivity: Human
- Target: TFEB
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
The master regulator of the Autophagy-Lysosome Pathway. It coordinates the expression of the CLEAR gene network, which enhances lysosomal biogenesis, autophagy induction, and cellular clearance. It is a major target for treating neurodegenerative and lysosomal storage diseases.
Protein class
Cancer-related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Syncytiotrophoblasts, Oligodendrocytes)
Immune cell specificity
Group enriched (neutrophil, memory B-cell, naive B-cell, eosinophil, intermediate monocyte, classical monocyte, myeloid DC, non-classical monocyte)
Cell line specificity
Cell line enhanced (BEWO, Daudi, OE19, U-698)
Interaction
Homodimer and heterodimer; with TFE3 or MITF.
Molecular function
Activator, DNA-binding
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