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THBS1
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Macrophages, Smooth muscle cells, Fibroblasts, Granulosa cells)
Immune cell specificity
Immune cell enhanced (eosinophil)
Cell line specificity
Cell line enhanced (fHDF/TERT166, HUVEC TERT2, LHCN-M2, TIME)
Interaction
Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS1 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts with ATF6 (via lumenal domain) (By similarity). Interacts with FN1; this interaction is enhanced by TNFAIP6, which may act as a bridging molecule between FN1 and THBS1.
Molecular function
Heparin-binding
More Types Infomation
Related Signaling Pathways
TGF-β Signaling Pathway
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, IF, IHC, IP, Neut
- Human Anti-THBS1 Antibody (clone TSP-A10), mRNA (FAMAB-0096JF-mRNA)
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- Species Reactivity: Human
- Mouse Anti-THBS1 Recombinant Antibody (clone A6.1) (NEUT-2021CQ)
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- Species Reactivity: Human, Mouse, Canine, Porcine, Rat, Horse, Sheep, Bovine
- Type: Mouse IgG1
- Application: ICC, IF, IHC-Fr, IHC-P, IP, Neut, WB
- Human Anti-THBS1 Recombinant Antibody (clone TSP-A10); scFv Fragment (FAMAB-0096JF-S(P))
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- Derivation: Human phage display scFv library
- Species Reactivity: Human
- Type: Human scFv
- Application: IB, WB, ELISA, FuncS
- Human Anti-THBS1 Recombinant Antibody (clone TSP-A10); Fab Fragment (FAMAB-0096JF-F(E))
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- Derivation: Human phage display scFv library
- Species Reactivity: Human
- Type: Human Fab
- Application: IB, WB, ELISA, FuncS
- Human Anti-THBS1 Recombinant Antibody (clone TSP-A10) (FAMAB-0096JF)
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- Derivation: Human phage display scFv library
- Species Reactivity: Human
- Type: Human IgG
- Application: WB, IHC, ICC
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- Species Reactivity: Cow
- Type: Mouse antibody
- Application: ELISA, IHC-Fr, IP
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA
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For Research Use Only. Not For Clinical Use.