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TK1
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- Mouse Anti-TK1 Recombinant Antibody (TAB-0420CL) (TAB-0420CL)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, DB
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- Rabbit Anti-TK1 Recombinant Antibody (clone JF0970) (MRO-1492-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, FC
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- Recombinant Rabbit Anti-TK1 Antibody (clone R05-9G6) (VS3-FY1456)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
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- Mouse Anti-TK1 Recombinant Antibody (clone 32A3) (MOB-1589z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA
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- Mouse Anti-TK1 Recombinant Antibody (TAB-0419CL) (TAB-0419CL)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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- Mouse Anti-TK1 Recombinant Antibody; scFv Fragment (TAB-0421CL-S(P)) (TAB-0421CL-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, DB
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- Mouse Anti-TK1 Recombinant Antibody; Fab Fragment (TAB-0419CL-F(E)) (TAB-0419CL-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Mouse Anti-TK1 Recombinant Antibody; Fab Fragment (TAB-0420CL-F(E)) (TAB-0420CL-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, DB
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- Mouse Anti-TK1 Recombinant Antibody; Fab Fragment (TAB-0421CL-F(E)) (TAB-0421CL-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, DB
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- Mouse Anti-TK1 Recombinant Antibody (TAB-0421CL) (TAB-0421CL)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, DB
Compare
- Mouse Anti-TK1 Recombinant Antibody; scFv Fragment (TAB-0419CL-S(P)) (TAB-0419CL-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Mouse Anti-TK1 Recombinant Antibody; scFv Fragment (TAB-0420CL-S(P)) (TAB-0420CL-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, DB
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- Human Anti-TK1 scFv-Fc Chimera (VS-0325-FY142) (VS-0325-FY142)
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- Species Reactivity: Human
- Type: Human IgG1, scFv-Fc
- Application: FC
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- Anti-TK1 Immunohistochemistry Kit (VS-0325-XY2296)
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- Species Reactivity: Human, Mouse, Rat
- Target: TK1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016]
Protein class
Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Extravillous trophoblasts, Erythroid cells, Cytotrophoblasts, Hofbauer cells)
Immune cell specificity
Immune cell enhanced (T-reg)
Cell line specificity
Low cell line specificity
Interaction
Homotetramer (PubMed:15611477, PubMed:15733844, PubMed:17407781, PubMed:22385435, PubMed:14697231). Tetramerization from dimerization is induced by ATP and increases catalytic efficiency due to a high affinity for thymidine (PubMed:14697231). Tetramerization is inhibited by phosphorylation at Ser-13 (PubMed:14697231). Interacts (via the KEN box) with FZR1 (PubMed:14701726).
Molecular function
Kinase, Transferase
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Related Signaling Pathways
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway