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TNFRSF1B

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The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, IF, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
IF, Neut, FuncS
Species Reactivity:
Human
Type:
IgG2a, κ
Application:
FC, Neut
Species Reactivity:
Mouse
Type:
IgG
Application:
FC, IP, BL, WB, ELISA
Species Reactivity:
Mouse
Type:
IgG
Application:
FC, IP, BL
Species Reactivity:
Human
Type:
IgG1
Application:
WB, ELISA(Cap), Neut
Species Reactivity:
Human
Type:
IgG2a
Application:
ICC, Neut
Species Reactivity:
Human
Type:
IgG
Application:
Neut
Scaffold Name:
Kunitz domains
Target:
TNFR2
Species Reactivity:
Human
Derivation:
Phage display
Etanercept (TP-087CL)
Protein Chemical Formula:
C2224H3475N621O698S36
Protein Average Weight:
51234.9 Da
CAS Number:
185243-69-0
Species Reactivity:
Human
Type:
Mouse antibody
Application:
ELISA, Neut, WB
Derivation:
Phage display library screening
Species Reactivity:
Human
Type:
IgG
Application:
WB, IHC, ICC, IP, FC
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