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Anti-TNFRSF1B Recombinant Antibody Products

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Anti-TNFRSF1B Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs is a leading provider of premium anti-TNFRSF1B recombinant antibody solutions, meticulously crafted to meet the rigorous demands of global scientific discovery. Our advanced antibodies deliver exceptional specificity and high affinity, empowering researchers and developers worldwide to accelerate their understanding of immune mechanisms and drive impactful therapeutic innovations.

TNFRSF1B: A Pivotal Target for Inflammatory and Autoimmune Diseases

Tumor Necrosis Factor Receptor Superfamily Member 1B (TNFRSF1B), also known as TNFR2 or p75/p80 TNF receptor, is a key cell surface receptor for TNF-α. It plays a critical role in immune homeostasis, cell survival, proliferation, and inflammation, often mediating anti-apoptotic and immunomodulatory signals. Aberrant TNFRSF1B signaling is implicated in various inflammatory and autoimmune conditions, including rheumatoid arthritis, inflammatory bowel diseases, and multiple sclerosis, making it a significant target for therapeutic intervention.

Alternative Names

Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; TNFR2; CD120b; TBPII; TNF-R-II; TNFR1B; TNFBR; TNFR80; p75; p75TNFR.

Background

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Human disease related genes, Plasma proteins

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Langerhans cells, dendritic cells, Macrophages, Kupffer cells, monocytes, T-cells)

Immune cell specificity

Immune cell enhanced (non-classical monocyte)

Cell line specificity

Cell line enhanced (CAPAN-2, K-562, THP-1, U-87 MG, U-937)

Interaction

Binds to TRAF2 (PubMed:8069916, PubMed:10206649). Interacts with BMX (PubMed:12370298). Interacts (activated form) with XPNPEP3 (PubMed:25609706).

Molecular function

Receptor

More Types Infomation

Anti-TNFRSF1B rAb Products

Our anti-TNFRSF1B recombinant antibody products are meticulously designed and produced using cutting-edge genetic engineering, ensuring superior specificity, consistency, and high affinity. These antibodies offer a distinct advantage over conventional antibodies due to their defined molecular structure and minimized batch-to-batch variation. This precision enables highly reliable and reproducible results across diverse experimental platforms, making them indispensable tools for advanced research and drug discovery.

Table 1. Featured anti-TNFRSF1B recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
MOR-0014-FY Mouse Anti-TNFRSF1B Recombinant Antibody (clone MR2-1) Human, Cynomolgus monkey, Rhesus monkey Mouse IgG1 FC, FuncS, IA, IF, IP, WB
VS-0724-XY49 Mouse Anti-TNFRSF1B Agonistic Antibody (clone MR2-1) Human Mouse IgG FC, IHC, Agonistic assays
HPAB-1550WJ Mouse Anti-TNFRSF1B Recombinant Antibody (clone 32) Human Mouse IgG1 ELISA, WB
NEUT-2154CQ Hamster Anti-Tnfrsf1b Recombinant Antibody (clone TR75-54.7) Mouse Hamster IgG FC, IP, Block, WB, ELISA
VS-0824-YJ45 Anti-TNFRSF1B Recombinant Antibody (VS-0824-YJ45) Human ELISA, WB, Inhib

Creative Quality Control

Creative Biolabs is unwaveringly committed to quality. Our anti-TNFRSF1B recombinant antibodies undergo rigorous quality control assessments, including comprehensive validation through techniques such as ELISA, Western Blot, flow cytometry, and many others. This stringent validation process confirms their specificity, binding characteristics, and functional activity, guaranteeing that every product meets the highest standards of purity, consistency, and performance for your critical research.

Customer Reviews

Excellent
Fa***n
Rabbit Anti-TNFRSF1B Recombinant Antibody (clone R36-5A-4) (VS3-FY2119)
The anti-TNFRSF1B recombinant antibody from Creative Biolabs has been instrumental in our research. Its high specificity and consistent performance across multiple assays, especially in immunohistochemistry, have significantly enhanced the clarity and reliability of our data. This product is a testament to their commitment to quality.
16/Jun/2024
Excellent
Mi***n
Hamster Anti-Tnfrsf1b Recombinant Antibody (NEUT-2155CQ) (NEUT-2155CQ)
We've had an excellent usage experience with Creative Biolabs' anti-TNFRSF1B antibody. The low background noise and strong signal intensity have allowed us to detect TNFRSF1B expression with unprecedented accuracy in our cellular models, accelerating our understanding of its role in disease progression. Highly recommended for demanding applications.
30/Aug/2024
Excellent
De***e
Mouse Anti-TNFRSF1B Recombinant Antibody (clone 33A8) (MOB-2054z)
Creative Biolabs' anti-TNFRSF1B recombinant antibody proved highly effective in our therapeutic development pipeline. Its robust performance in neutralization assays confirmed its potential as a valuable tool for modulating TNF-α signaling in preclinical studies, paving the way for novel therapeutic strategies. We are very satisfied with its application.
22/Feb/2025

rAb Production

Our anti-TNFRSF1B recombinant antibody products are manufactured using advanced expression systems in state-of-the-art facilities. This sophisticated production process ensures high yields of exceptionally pure antibodies, free from common contaminants. This commitment to advanced manufacturing technology guarantees the consistent quality, reliable performance, and integrity of every antibody batch, empowering your research with superior reagents.

Featured Anti-TNFRSF1B Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-TNFRSF1B recombinant antibody production.

Fig.2 Gram-scale anti-TNFRSF1B recombinant antibody production.

rAb Modalities

Our anti-TNFRSF1B recombinant antibodies are available in various formats and conjugations, suitable for a wide range of applications including Western Blot, ELISA, flow cytometry, and IHC.

Fig.3 Full-length anti-TNFRSF1B recombinant antibody production and modalities.

TNFRSF1B-Targeted Drug Information

Table 2. Public drug targeting TNFRSF1B.

Company Research phase Classification Condition
Nanjing Leads Biolabs (Originator) Phase I/II Cancer Immunotherapy
Monoclonal Antibodies
Cancer
BioInvent (Originator) Phase I/II Agonist Antibodies
Cancer Immunotherapy
Human Monoclonal Antibodies
Cancer, liver (hepatocellular carcinoma)
Cancer, lung (non-small cell) (NSCLC)
Cancer, solid tumor
BioInvent (Originator) Phase I/II Cancer Immunotherapy
Monoclonal Antibodies
Cancer, lung (non-small cell) (NSCLC)
Cancer, ovary
Cancer, solid tumor
Cutaneous T-cell lymphoma
Simcere Pharmaceutical (Originator) Phase I Cancer Immunotherapy
Humanized Monoclonal Antibodies
Cancer
Cancer, solid tumor
Cutaneous T-cell lymphoma
Novarock Biotherapeutics (Originator) Phase I Cancer Immunotherapy
Human Monoclonal Antibodies
Cancer, solid tumor
HiFiBiO (Originator) Phase I Cancer Immunotherapy
Humanized Monoclonal Antibodies
Cancer, solid tumor
BeiGene
Boston Immune Technologies and Therapeutics (Originator)
IND Filed Cancer Immunotherapy
Humanized Monoclonal Antibodies
Cancer
Cutaneous T-cell lymphoma
Infections
Leukemia-lymphoma, adult T-cell
Lymphoma, diffuse large B-cell
Lymphoma, mantle cell
Lymphoma, marginal zone
Non-Hodgkin lymphoma
Peripheral T-cell lymphoma
Biolojic Design (Originator)
Nektar Therapeutics
Preclinical Agonist Antibodies
Monoclonal Antibodies
Autoimmune disease
Dragon Boat Biopharmaceutical (Originator) Preclinical Cancer Immunotherapy
Monoclonal Antibodies
Cancer, solid tumor
Odyssey Therapeutics (Originator) Preclinical Agonist Antibodies
Cancer Immunotherapy
Monoclonal Antibodies
Single-Domain Antibodies
Autoimmune disease
TRex Bio (Originator) Preclinical Inflammatory disorders
Julius-Maximilians-Universitaet (Originator)
Rijksuniversiteit Groningen (RUG) (Originator)
Preclinical Fc Fusion Proteins
Polypeptides, from 41 AA
Dementia, Alzheimer type
Dualyx (Originator) Preclinical Agonist Antibodies
Antibodies
Autoimmune disease

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Creative Biolabs is dedicated to accelerating scientific discovery by offering premium anti-TNFRSF1B recombinant antibody products to the global research community. We encourage you to discover how these high-quality reagents can elevate your studies in immunology, inflammation, and therapeutic development. To learn more or to discuss your specific requirements, please do not hesitate to get in touch with us.

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