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VDAC1
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer and homotrimer; in response to cyclic AMP or calcium (PubMed:30061676). Interacts with hexokinases including HK1 (PubMed:8420959, PubMed:22304920). The HK1-VDAC1 complex interacts with ATF2 (PubMed:22304920). Interacts with BCL2L1 (PubMed:18755977, PubMed:25296756). Interacts with BAK1 (PubMed:25296756). Interacts with RTL10/BOP (via BH3 domain) (PubMed:23055042). Interacts with amyloid-beta and APP; induces VDAC1 dephosphorylation (PubMed:25168729). Component of the mitochondrial permeability transition pore complex (mPTPC), at least composed of SPG7, VDAC1 and PPIF (PubMed:26387735). Interacts with SPG7, NIPSNAP2 and SLC25A30 (PubMed:26387735). Interacts with TMEM41B (PubMed:30352685). Interacts with BCAP31 (PubMed:31206022). (Microbial infection) Interacts with influenza A virus PB1-F2 protein.
Molecular function
Porin
More Types Infomation
- Rabbit Anti-VDAC1 Recombinant Antibody (clone CBACN-577) (MRO-1576-CN)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC
- Recombinant Mouse Anti-Human VDAC1 Antibody (MOB-2177MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
- Wheat Anti-VDAC1 Recombinant Antibody (clone YC179) (MOB-0212MC)
-
- Type: Wheat IgG
- Application: AP, ELISA, WB
- Wheat Anti-VDAC1 Recombinant Antibody (clone YC178) (MOB-0211MC)
-
- Type: Wheat IgG
- Application: AP, ELISA, WB
- Wheat Anti-VDAC1 Recombinant Antibody (clone YC177) (MOB-0210MC)
-
- Type: Wheat IgG
- Application: AP, ELISA, WB
- Rabbit Anti-VDAC1 Polyclonal Antibody (MRO-2268-CN) (MRO-2268-CN)
-
- Species Reactivity: Human, Zebrafish
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, ICC, IF, IHC
-
- Derivation: Phage display library
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: ELISA, WB, IHC
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