Rabbit Anti-VDAC1 Recombinant Antibody (VS13-YC1214)

CAT#: VS13-YC1214

The Rabbit Anti-VDAC1 Recombinant Antibody is specific for human, mouse and rat VDAC1. VDAC1 encodes a voltage-dependent anion channel in the mitochondrial outer membrane, facilitating metabolite exchange and regulating mitochondrial functions. The anti-VDAC1 antibody can be used for Western blot (1/500), Immunocytochemistry (1/50), Immunohistochemistry-paraffin (1/50-1/200).

Gene Expression
Figure 1 Lymph node Figure 2 Cerebral cortex Figure 3 Colon Figure 4 Liver Figure 5 Kidney Figure 6 Heart muscle Figure 7 RNA cell line category: Low cell line specificity

Specifications

  • Immunogen
  • Recombinant human VDAC1.
  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human, Mouse and Rat VDAC1
  • Species Reactivity
  • Human, Mouse, Rat
  • Conjugate
  • NONE

Product Property

  • Clonality
  • Monoclonal
  • Purification
  • Protein A purified
  • Format
  • Liquid
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
  • Preservative
  • 0.05% Sodium azide
  • Storage
  • Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Shipping with ice pack.

Applications

  • Application Notes
  • Western blot (WB): 1/500
    Immunocytochemistry (ICC): 1/50
    Immunohistochemistry-paraffin (IHC-P): 1/50-1/200

Target

  • Alternative Names
  • Voltage Dependent Anion Channel 1; Outer Mitochondrial Membrane Protein Porin 1; Plasmalemmal Porin; Porin 31HL; Porin 31HM; VDAC-1;
  • Long Name
  • Voltage Dependent Anion Channel 1
  • Sequence Similarities
  • Belongs to the eukaryotic mitochondrial porin family.
  • Cellular Localization
  • Mitochondrion outer membrane; Cell membrane raft
  • Function
  • Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959).
    Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (PubMed:31015432).
    In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033).
    May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756).
    May mediate ATP export from cells (PubMed:30061676).
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

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Protocol & Troubleshooting

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

Secondary Antibody

Isotype Control

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