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WNT3A

Anti-WNT3A Products

Rat Anti-WNT3A Recombinant Antibody (clone CBL672) (NEUT-2281CQ)
- Species Reactivity: Human, Mouse
- Type: Rat IgG1
- Application: Neut
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Rat Anti-WNT3A Recombinant Antibody (clone CBL001) (NEUT-2280CQ)
- Species Reactivity: Human
- Type: Rat IgG2
- Application: WB, Neut
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Rat Anti-Wnt3a Recombinant Antibody (clone RM0358-13F9) (NEUT-2279CQ)
- Species Reactivity: Mouse
- Type: Rat IgG2
- Application: WB, Neut
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Rat Anti-Wnt3a Recombinant Antibody (clone CBL002) (NEUT-2278CQ)
- Species Reactivity: Mouse
- Type: Rat IgG2
- Application: WB, Neut
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Mouse Anti-WNT3A Recombinant Antibody (clone EG-64) (VS3-WK68)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, ICC, IHC, FC
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Mouse Anti-WNT3A Recombinant Antibody (clone 6H11-H11-G7) (VS3-QX1247)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
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Mouse Anti-WNT3A Recombinant Antibody (ZG-0508F) (ZG-0508F)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
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Recombinant Mouse anti-Human WNT3A Monoclonal antibody (4B7) (MOB-2234CT)
- Species Reactivity: Human
- Application: ELISA, WB
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Anti-Mouse WNT3A Immunohistochemistry Kit (VS-0525-XY7930)
- Species Reactivity: Human, Mouse, Rat
- Target: WNT3A
- Application: IHC
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Anti-Human WNT3A Immunohistochemistry Kit (VS-0525-XY7929)
- Species Reactivity: Human, Porcine
- Target: WNT3A
- Application: IHC
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Anti-WNT3A Immunohistochemistry Kit (VS-0525-XY7928)
- Species Reactivity: Human
- Target: WNT3A
- Application: IHC
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For Research Use Only. Not For Clinical Use.

Background

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Alveolar cells type 1, Basal squamous epithelial cells, Basal keratinocytes, Basal prostatic cells, Syncytiotrophoblasts)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (HEK93, U-2 OS)

Interaction

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Homooligomer; disulfide-linked, leading to inactivation (By similarity). Interacts with PORCN (PubMed:20826466). Interacts with APCDD1 and WLS (PubMed:16678095, PubMed:20393562). Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6 (PubMed:20093360). Interacts with glypican GPC3 (PubMed:16227623). Interacts with PKD1 (via extracellular domain) (PubMed:27214281).

Molecular function

Developmental protein

More Types Infomation

Related Signaling Pathways

Canonical Wnt Signaling Pathway

mTOR Signaling Pathway

Non-Canonical Wnt Signaling Pathway

Related Diseases

Endometrial Cancer

Throid Cancer

Cushing Syndrome