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WNT3A
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Alveolar cells type 1, Basal squamous epithelial cells, Basal keratinocytes, Basal prostatic cells, Syncytiotrophoblasts)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (HEK93, U-2 OS)
Interaction
Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Homooligomer; disulfide-linked, leading to inactivation (By similarity). Interacts with PORCN (PubMed:20826466). Interacts with APCDD1 and WLS (PubMed:16678095, PubMed:20393562). Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6 (PubMed:20093360). Interacts with glypican GPC3 (PubMed:16227623). Interacts with PKD1 (via extracellular domain) (PubMed:27214281).
Molecular function
Developmental protein
More Types Infomation
Related Signaling Pathways
Canonical Wnt Signaling Pathway
mTOR Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Related Diseases
Endometrial Cancer
Throid Cancer
Cushing Syndrome
- Rat Anti-WNT3A Recombinant Antibody (clone CBL672) (NEUT-2281CQ)
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- Species Reactivity: Human, Mouse
- Type: Rat IgG1
- Application: Neut
- Rat Anti-WNT3A Recombinant Antibody (clone CBL001) (NEUT-2280CQ)
-
- Species Reactivity: Human
- Type: Rat IgG2
- Application: WB, Neut
- Rat Anti-Wnt3a Recombinant Antibody (clone RM0358-13F9) (NEUT-2279CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2
- Application: WB, Neut
- Rat Anti-Wnt3a Recombinant Antibody (clone CBL002) (NEUT-2278CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2
- Application: WB, Neut
-
- Species Reactivity: Human
- Application: ELISA, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, ICC, IHC, FC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.