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    WNT5A

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    For Research Use Only. Not For Clinical Use.


    Background

    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
    Protein class

    Disease related genes, Human disease related genes, Plasma proteins

    Predicted location

    Secreted

    Single cell type specificity

    Cell type enhanced (Endometrial stromal cells, Alveolar cells type 1, Basal squamous epithelial cells, Club cells, Oligodendrocyte precursor cells)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Cell line enhanced (BJ, BJ hTERT+, HeLa, SiHa, U-87 MG)

    Interaction

    Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Homooligomer; disulfide-linked, leading to inactivation (in vitro). Interacts with PORCN. Interacts with WLS (By similarity). Interacts with glypican GCP3 (PubMed:14610063). Interacts with PKD1 (via extracellular domain) (PubMed:27214281).

    Molecular function

    Developmental protein

    More Types Infomation
    Related Signaling Pathways
    Canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway
    mTOR Signaling Pathway mTOR Signaling Pathway
    Non-Canonical Wnt Signaling Pathway Non-Canonical Wnt Signaling Pathway
    Related Diseases
    Endometrial Cancer Endometrial Cancer
    Throid Cancer Throid Cancer
    Cushing Syndrome Cushing Syndrome
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