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WNT5A

Recombinant Antibody Products Formats

Anti-WNT5A Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
Protein class

Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Endometrial stromal cells, Alveolar cells type 1, Basal squamous epithelial cells, Club cells, Oligodendrocyte precursor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BJ, BJ hTERT+, HeLa, SiHa, U-87 MG)

Interaction

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Homooligomer; disulfide-linked, leading to inactivation (in vitro). Interacts with PORCN. Interacts with WLS (By similarity). Interacts with glypican GCP3 (PubMed:14610063). Interacts with PKD1 (via extracellular domain) (PubMed:27214281).

Molecular function

Developmental protein

More Types Infomation
Related Signaling Pathways
Canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway
mTOR Signaling Pathway mTOR Signaling Pathway
Non-Canonical Wnt Signaling Pathway Non-Canonical Wnt Signaling Pathway
Related Diseases
Endometrial Cancer Endometrial Cancer
Throid Cancer Throid Cancer
Cushing Syndrome Cushing Syndrome
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