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WNT5B

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For Research Use Only. Not For Clinical Use.


Background

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Muller glia cells, Basal squamous epithelial cells, Microglial cells, Urothelial cells)

Immune cell specificity

Immune cell enhanced (classical monocyte, eosinophil)

Cell line specificity

Cell line enhanced

Interaction

Interacts with PORCN.

Molecular function

Developmental protein

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