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DLL3

This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.
Protein class

Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Group enriched (Spermatogonia, Oligodendrocyte precursor cells)

Immune cell specificity

Immune cell enhanced (memory B-cell, naive CD8 T-cell)

Cell line specificity

Cell line enriched (SK-MEL-30)

Interaction

Can bind and activate Notch-1 or another Notch receptor.

Molecular function

Developmental protein

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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