Anti-DLL3 (Rovalpituzumab )-Mc-vc-PBD ADC (Rovalpituzumab tesirine) (CAT#: ADC-L042)

• Antibody Overview
• Humanized IgG1k antibody huSC16 (anti-DLL3)

• Clone
• Rovalpituzumab

• Antibody Conjugation
• Humanized

• Linker
• mc-vc (maleimidocaproyl-valine-alanine)

• Linker Class/Description
• Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• pyrrolobenzodiazepine (PBD) dimer SCX

• Drug Class/Description
• Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.

• Introduction
• This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.

• Alternative Names
• SCDO1; DLL3; delta like canonical Notch ligand 3

• Gene ID
• 10683

• UniProt ID
• Q9NYJ7

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