Anti-TENB2 (clone TMEFF2#19)-MC-MMAF ADC (CAT#: ADC-119CL)

• Antibody Overview
• Humanized Anti-TENB2 Antibody, hu TMEFF2#19

• Clone
• TMEFF2#19

• Linker
• Mc (maleimidocaproyl)

• Linker Class/Description
• Class: Noncleavable linkers
  Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

• Drug
• MMAF (Monomethyl auristatin F)

• Drug Class/Description
• Class: Auristatin
  Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• TENB2 encodes a putative transmembrane proteoglycan, related to the EGF/heregulin family of growth factors and follistatin, which has been identified through the application of a differential display technique to a xenograft model of prostate cancer.

• Alternative Names
• TMEFF2; transmembrane protein with EGF-like and two follistatin-like domains 2; TR; HPP1; TPEF; TENB2; CT120.2; tomoregulin-2; TR-2; tomoregulin; transmembrane protein TENB2; hyperplastic polyposis protein 1; cancer/testis antigen family 120, member 2;

• Gene ID
• 23671

• UniProt ID
• Q9UIK5

• ADC-120CL
• Anti-TENB2 (clone TMEFF2#19)-MC-vc-PAB-MMAE ADC

• HPAB-0022-LS
• Mouse Anti-TMEFF2 Recombinant Antibody (clone TMEFF2#19)

• HPAB-0022-LS-S(P)
• Mouse Anti-TMEFF2 Recombinant Antibody (clone TMEFF2#19); scFv Fragment

• HPAB-0022-LS-F(E)
• Mouse Anti-TMEFF2 Recombinant Antibody (clone TMEFF2#19); Fab Fragment

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