transferrin-ABR immunotoxin (CAT#: AGTO-G074A)
This immunotoxin was achieved by conjugating/fusing the transferrin to Abrin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the abrin is subsequently engulfed and enters the inner parts of the cell where it reacts with a ribosomal subunit. It interferes with the normal protein synthesis process of the cell and then inhibits cell protein synthesis. It was designed for treatment of myelogenous leukemia.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64166/1156_A8_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64166/1156_A8_2_selected.jpg
Figure 2 IF staining of human cell line K-562
(Immunofluorescent staining of human cell line K-562 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77984/1892_E7_3_selected.jpg
(Immunofluorescent staining of human cell line K-562 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77984/1892_E7_3_selected.jpg
Figure 3 RNA cell line category: Cell line enhanced (TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000145734-BDP1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000145734-BDP1
Specifications
- Host Species
- Human
- Species Reactivity
- Human
- Molecule Class
- transferrin-ABR
- Toxin Description
- Abrin is a highly toxic toxalbumin found in the seeds of the rosary pea (jequirity pea). It is a ribosome inhibiting protein and the toxin can also be found in the seeds of the castor oil plant. Abrin is a water-soluble lectin. Abrin in powdered form is yellowish-white. It is a stable substance and can withstand extreme environmental conditions.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- myelogenous leukemia
Target
- Alternative Names
- BDP1; B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB; TFC5; TFNR; TAF3B1; TFIIIB; TFIIIB90; HSA238520; TFIIIB150; transcription factor TFIIIB component B homolog; transcription factor IIIB 150; transcription factor-like nuclear regulator; RNA polymerase III transcription initiation factor B; TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1; Abrin; Abrin variant; Abrin-A; Abrin A; ABR
- Gene ID
- 55814
- UniProt ID
- A6H8Y1
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Immunotoxins
IgG Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G074P | transferrin-PAP immunotoxin | Cytotoxicity assay, Function study |
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