transferrin-PAP immunotoxin (CAT#: AGTO-G074P)
This immunotoxin was achieved by conjugating/fusing the transferrin to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of myelogenous leukemia.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64166/1156_A8_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64166/1156_A8_2_selected.jpg
Figure 2 IF staining of human cell line K-562
(Immunofluorescent staining of human cell line K-562 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77984/1892_E7_3_selected.jpg
(Immunofluorescent staining of human cell line K-562 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77984/1892_E7_3_selected.jpg
Figure 3 RNA cell line category: Cell line enhanced (TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000145734-BDP1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000145734-BDP1
Specifications
- Host Species
- Human
- Species Reactivity
- Human
- Molecule Class
- transferrin-PAP
- Toxin Description
- Pokeweed antiviral protein (PAP) is a type I ribosome inactivating protein isolated from the pokeweed plant, Phytolacca americana. The toxin is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- myelogenous leukemia
Target
- Alternative Names
- BDP1; B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB; TFC5; TFNR; TAF3B1; TFIIIB; TFIIIB90; HSA238520; TFIIIB150; transcription factor TFIIIB component B homolog; transcription factor IIIB 150; transcription factor-like nuclear regulator; RNA polymerase III transcription initiation factor B; TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1; Pokeweed Antiviral Protein; Pokeweed; PAP
- Gene ID
- 55814
- UniProt ID
- A6H8Y1
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Immunotoxin Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G074A | transferrin-ABR immunotoxin | Cytotoxicity assay, Function study |
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