transferrin-PAP immunotoxin (AGTO-G074P)
This immunotoxin was achieved by conjugating/fusing the transferrin to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of myelogenous leukemia.
Specifications
- Host
- Human
- Species Reactivity
- Human
- Molecule Class
- transferrin-PAP
- Toxin Description
- Pokeweed antiviral protein (PAP) is a type I ribosome inactivating protein isolated from the pokeweed plant, Phytolacca americana. The toxin is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- myelogenous leukemia
Target
- Alternative Names
- BDP1; B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB; TFC5; TFNR; TAF3B1; TFIIIB; TFIIIB90; HSA238520
- Entrez Gene ID
- 55814
- UniProt ID
- A6H8Y1
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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