Products

transferrin-PAP immunotoxin (AGTO-G074P)

This immunotoxin was achieved by conjugating/fusing the transferrin to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of myelogenous leukemia.      

  • Datasheet

Specifications
Host
Human
Species Reactivity
Human
Molecule Class
transferrin-PAP
Toxin Description
Pokeweed antiviral protein (PAP) is a type I ribosome inactivating protein isolated from the pokeweed plant, Phytolacca americana. The toxin is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
myelogenous leukemia
Target
Alternative Names
BDP1; B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB; TFC5; TFNR; TAF3B1; TFIIIB; TFIIIB90; HSA238520
Entrez Gene ID
55814
UniProt ID
A6H8Y1

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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