10-FnIII scaffold protein anti-Human IL-23
CAT#: SFN-L010
The tenth fibronectin type III domain (10Fn3) that bound IL-23 was isolated from the library using Phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=0.26 nM) for IL-23 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Specifications
- Scaffold Name
- 10-FnIII
- Origin
- Fibronectin
- Core Structure
- β-sandwich of 7 β-strands
- Variable Regions
- 2–3 Loops
- Target
- IL-23
- Species Reactivity
- Human
- Expression Host
- E. coli
- Affinity Constant
- 0.26 nM
- Applications
- ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study
Target
- Alternative Names
- Fibronectin; 10-FnIII; IL23; IL-23
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Related Diseases
Inflammatory Bowel Diseases
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