Human Anti-IL23 (clone ABT-874) scFv-Fc Chimera (CAT#: VS-0325-FY183)
The anti-IL-23 scFv-Fc antibody targets Interleukin-23 (IL-23), a cytokine involved in immune regulation and inflammation. This antibody combines the specificity of the scFv with the Fc region's stability, offering a powerful tool for studying IL-23's role in autoimmune diseases and inflammatory processes, as well as potential therapeutic applications.
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Specifications
- Immunogen
- The recombinant human IL-12/IL-23 p40 subunit.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL23
- Species Reactivity
- Human
- Clone
- ABT-874
- Applications
- Immunoassay
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Human Interleukin-23; IL-23
- Long Name
- Human Interleukin-23
- Sequence Similarities
- Belongs to the type I cytokine receptor family. Type 2 subfamily.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Phosphorylated in response to IL23.
Glycosylation at Asn262, Asn273, Asn29, Asn47, Asn81, Asn141, Asn180, and Asn232
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 9 sites
- Protein Refseq
- XP_011539092.1; XP_011539093.1; XP_047303183.1; XP_054190613.1; XP_054190614.1
- Function
- Human IL23 (Interleukin 23) is a cytokine involved in inflammatory responses, particularly in autoimmune diseases. It plays a role in T cell differentiation and is a target for therapeutic interventions in conditions like psoriasis and inflammatory bowel disease.
Recommended Products
Isotype Control
Secondary Antibody
Related Resources
Inflammatory Bowel Diseases
Rheumatoid Arthritis
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Human Antibodies
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Neutralizing Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-419CL | Human Anti-IL23 Recombinant Antibody (TAB-419CL) | Inhib, FuncS | Human IgG |
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