APC-A*02:01/Human MLANA (ELAGWGILTV) MHC Tetramer

CAT#: MHC-LC1659

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of MLANA-derived peptide of ELAGWGILTV covering 26-35 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

Gene Expression
Figure 1 High expression in skin 1 Figure 2 Low expression in liver Figure 3 Testis Figure 4 RNA cell line category: Cell line enriched (SK-MEL-30)

Specifications

  • Allele
  • A*02:01
  • Class
  • Class I
  • MHC Species
  • Human
  • Antigen
  • Mart-1
  • Antigen Species
  • Human
  • Peptide
  • ELAGWGILTV
  • Range
  • 26-35
  • Conjugate
  • APC

Target

  • Antigen Introduction
  • Protein melan-A also known as melanoma antigen recognized by T cells 1 or MART-1 is a protein that in humans is encoded by the MLANA o "MALENA" gene. A fragment of the protein, usually consisting of the nine amino acids 27 to 35, is bound by MHC class I complexes which present it to T cells of the immune system. These complexes can be found on the surface of melanoma cells. Decameric peptides (26-35) are being investigated as cancer vaccines.
  • Alternative Names
  • MLANA; melan-A; MART1; MART-1
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