APC-HLA-A2/Human MLANA (AAGIGILTV) MHC Tetramer
CAT#: MHC-LC1368
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of MLANA-derived peptide of AAGIGILTV covering 27-35 and HLA-A2 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Normal Tissue
Figure 1 High expression in skin 1
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_B_8_1_val_selected.jpg
Normal Tissue
Figure 2 Low expression in liver
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_A_8_4_val_selected.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_A_5_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enriched (SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120215-MLANA
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Specifications
- Allele
- HLA-A2
- Class
- Class I
- MHC Species
- Human
- Antigen
- Mart-1
- Antigen Species
- Human
- Peptide
- AAGIGILTV
- Range
- 27-35
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- Protein melan-A also known as melanoma antigen recognized by T cells 1 or MART-1 is a protein that in humans is encoded by the MLANA o "MALENA" gene. A fragment of the protein, usually consisting of the nine amino acids 27 to 35, is bound by MHC class I complexes which present it to T cells of the immune system. These complexes can be found on the surface of melanoma cells. Decameric peptides (26-35) are being investigated as cancer vaccines.
- Alternative Names
- MLANA; melan-A; MART1; MART-1
- Gene ID
- 2315
- UniProt ID
- Q16655
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Great Signal For MART-1 Research
We ordered this tetramer to investigate T cell responses to the MART-1 antigen in HLA-A2 positive samples. The separation of the tetramer-positive population was distinct, facilitating accurate analysis of this cancer-testis antigen. The product arrived in good condition and performed as described in the datasheet.
Efficient Staining Of Melanoma Antigens
The APC-conjugated tetramer loaded with the MLANA peptide AAGIGILTV worked perfectly for our melanoma research. We were able to identify and enumerate specific CD8 T cells in human samples with high precision. The reagent quality is consistent, which is crucial for our longitudinal studies on antigen presentation.
Q&As
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Which human HLA allele is this tetramer restricted to?
A: This tetramer consists of the HLA-A2 molecule (specifically HLA-A*02) loaded with the MLANA-derived peptide. It is designed to detect antigen-specific CD8 T cells in samples from individuals who are positive for the HLA-A2 allele.
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What is the source protein for the peptide loaded in this complex?
A: The peptide AAGIGILTV (residues 27-35) is derived from the MLANA protein, also known as Melan-A or MART-1. This protein is a well-known melanoma antigen recognized by T cells, making this tetramer suitable for cancer immunology research involving this target.
View the frequently asked questions answered by Creative Biolabs Support.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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