APC-HLA-A2/Human WT1 (YMFPNAPYL) MHC Tetramer (CAT#: MHC-LC1572)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of WT1-derived peptide of YMFPNAPYL covering 126-134 and HLA-A2 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specific Inquiry
Specifications
- Allele
- HLA-A2
- Class
- Class I
- MHC Species
- Human
- Antigen
- WT1
- Antigen Species
- Human
- Peptide
- YMFPNAPYL
- Range
- 126-134
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
- Alternative Names
- WT1; Wilms tumor 1; GUD; AWT1; WAGR; WT33; NPHS4; WIT-2; EWS-WT1
- Gene ID
- 7490
- UniProt ID
- P19544
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1458z | Mouse Anti-WT1 Recombinant Antibody (clone 24C8) | FC, IF, IHC | Mouse IgG1, κ |
| MOB-0344MZ | Recombinant Mouse Anti-Human Wilms Tumor 1 Antibody (clone 7G-H3) | IHC | Mouse antibody |
| ZG-0040U | Rabbit Anti-WT1 Recombinant Antibody (clone 5F2) | ELISA, WB, IHC | Rabbit IgG |
| VS3-FY1556 | Recombinant Mouse Anti-WT1 Antibody (clone 7F9E8) | ELISA, WB, IHC, FC | Mouse IgG1 |
| VS3-FY1557 | Recombinant Mouse Anti-WT1 Antibody (clone 9D1-8B8-4B8) | IHC-P | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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