Anti-WT1 immunotoxin 6F-H2 (IgG)-RTA
CAT#: AGTO-G065R
This immunotoxin was achieved by conjugating/fusing the Anti-WT1 monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of T cell leukemia.
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- 6F-H2
- Molecule Class
- IgG-RTA
- Toxin Description
- Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- T cell leukemia
Target
- Alternative Names
- WT1; Wilms tumor 1; GUD; AWT1; WAGR; WT33; NPHS4; WIT-2; EWS-WT1; Wilms tumor protein; amino-terminal domain of EWS|last three zinc fingers of the DNA-binding domain of WT1; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA
- Gene ID
- 7490
- UniProt ID
- P19544
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-1024-XY545 | Mouse Anti-NHP WT1 Recombinant Antibody (clone 7F9E8) | WB, IHC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
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| VS-0525-XY7945 | Anti-WT1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7946 | Anti-Mouse WT1 Immunohistochemistry Kit | IHC |
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