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    Anti-Human ADAMTS4 Recombinant Antibody Fab Fragment (7G4.1D6) (CAT#: TAB-0678CLV-F(E))

    The anti-ADAMTS4 antibody target ADAMTS4 that is kind of aggrecanases of which the activities can result in the degradation of the cartilage matrix. By inhibiting ADAMTS4 and thereby reducing the breakdown of extracellular matrix aggrecan in cartilage and other tissues, the antibody can be used in the treatment of diseases of cartilage.

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    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-251 MG
    Figure 1 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear speckles.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/51296/1017_D3_1_selected.jpg
    Normal Tissue
    Figure 2 IHC staining of human cerebral cortex
    Figure 2 IHC staining of human cerebral cortex
    (Immunohistochemical staining of human cerebral cortex shows strong positivity with a granular patter in neurons.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/25876/ihc_selected.jpg
    Figure 3 Cerebral cortex
    Figure 3 Cerebral cortex
    (Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/25876/57541_B_7_5.jpg
    Figure 4 Colon
    Figure 4 Colon
    (Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/25876/57541_A_7_3.jpg
    Figure 5 Liver
    Figure 5 Liver
    (Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/25876/57541_A_8_4.jpg
    Figure 6 Kidney
    Figure 6 Kidney
    (Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/25876/57541_A_8_5.jpg
    Figure 7 Testis
    Figure 7 Testis
    (Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/25876/57541_A_4_6.jpg
    Figure 8 Lymph node
    Figure 8 Lymph node
    (Germinal center cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/25876/57541_A_9_8.jpg
    RNA Expression
    Figure 9 RNA cell line category: Cell line enhanced.
    Figure 9 RNA cell line category: Cell line enhanced.
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000158859-ADAMTS4

    Specifications

    • Immunogen
    • ADAMTS4, ADAMTS5
    • Host Species
    • Mouse
    • Specificity
    • Human
    • Species Reactivity
    • Cross-react with rat ADAMTS4
    • Clone
    • 7G4.1D6
    • Related Disease
    • Diseases of cartilage

    Target

    • Alternative Names
    • ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADAM-TS 4; ADMP-1; EC 3.4.24.82; KIAA0688; A disintegrin and metalloproteinase with thrombospondin motifs 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospo

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

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    Please select product type
    Mouse Antibody Products IgG Antibody Products Neutralizing Antibody Products ScFv Antibody Products Fab Antibody Products Antibody Magnetic Beads
    CAT Product Name Application Type
    TAB-0676CLV Anti-Human ADAMTS4 Recombinant Antibody (7C7.1H1) Inhib
    TAB-0677CLV Anti-Human ADAMTS4 Recombinant Antibody (7E8.1E3) Inhib

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