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    Human Anti-ANGPT2 Recombinant Antibody (clone 5A12) (CAT#: PABL-398)

    Recombinant Human Antibody (5A12) is capable of binding to ANGPT2, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-ANGPT2 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-ANGPT2 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody is a potential therapeutic for neovascular age-related macular degeneration (NV AMD).

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
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    Conjugation :
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    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 Cerebral cortex
    Figure 1 Cerebral cortex
    (Neuronal cells
    Staining:High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Neuropil
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11437/27034_B_8_5.jpg
    Figure 2 Colon
    Figure 2 Colon
    (Endothelial cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Glandular cells
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous nuclear
    Peripheral nerve/ganglion
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11437/27028_A_9_3.jpg
    Figure 3 Liver
    Figure 3 Liver
    (Hepatocytes
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11437/27028_A_8_4.jpg
    Figure 4 Kidney
    Figure 4 Kidney
    (Cells in tubules
    Staining:Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11437/27028_A_8_5.jpg
    RNA Expression
    Figure 5 RNA cell line category: Group enriched (HMC-1, HSkMC, HUVEC TERT2, WM-115)
    Figure 5 RNA cell line category: Group enriched (HMC-1, HSkMC, HUVEC TERT2, WM-115)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091879-ANGPT2

    Specifications

    • Immunogen
    • Human angiopoietin 2
    • Host Species
    • Human
    • Derivation
    • Human
    • Type
    • Human IgG
    • Specificity
    • ANGPT2
    • Species Reactivity
    • Human
    • Clone
    • 5A12
    • Applications
    • WB, ELISA, FuncS

    Product Property

    • Purity
    • >95% as determined by analysis by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Buffer
    • PBS
    • Preservative
    • No preservatives
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Target

    • Alternative Names
    • ANGPT2; angiopoietin 2; ANG2; AGPT2; angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

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    Please select product type
    Single Domain Antibodies Human Antibodies Mouse Antibodies Humanized Antibodies Rabbit Monoclonal Antibodies ADCC Enhanced Antibodies Fab Antibodies IgG Antibodies ScFv Antibodies Antibody Magnetic Beads ScFv-Fc Chimeras IHC Kits & Antibodies
    CAT Product Name Application Type
    NABL-070 Recombinant Anti-human ANGPT2 VHH Single Domain Antibody WB, IHC, FC, FuncS Llama VHH
    TAB-0032CL-VHH Anti-Human ANGPT2 VHH Single Domain Antibody ELISA, Block, SPR Single domain antibody
    TAB-0035CL-VHH Anti-Human ANGPT2 VHH Single Domain Antibody ELISA, Block, SPR Single domain antibody

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