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    Human Anti-ANGPT2 Recombinant Antibody (clone 5A12) (CAT#: PABL-398)

    Recombinant Human Antibody (5A12) is capable of binding to ANGPT2, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-ANGPT2 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-ANGPT2 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody is a potential therapeutic for neovascular age-related macular degeneration (NV AMD).

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
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    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 Cerebral cortex
    Figure 1 Cerebral cortex
    (Neuronal cells
    Staining:High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Neuropil
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11437/27034_B_8_5.jpg
    Figure 2 Colon
    Figure 2 Colon
    (Endothelial cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Glandular cells
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous nuclear
    Peripheral nerve/ganglion
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11437/27028_A_9_3.jpg
    Figure 3 Liver
    Figure 3 Liver
    (Hepatocytes
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11437/27028_A_8_4.jpg
    Figure 4 Kidney
    Figure 4 Kidney
    (Cells in tubules
    Staining:Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11437/27028_A_8_5.jpg
    RNA Expression
    Figure 5 RNA cell line category: Group enriched (HMC-1, HSkMC, HUVEC TERT2, WM-115)
    Figure 5 RNA cell line category: Group enriched (HMC-1, HSkMC, HUVEC TERT2, WM-115)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091879-ANGPT2

    Specifications

    • Immunogen
    • Human angiopoietin 2
    • Host Species
    • Human
    • Derivation
    • Human
    • Type
    • Human IgG
    • Specificity
    • ANGPT2
    • Species Reactivity
    • Human
    • Clone
    • 5A12
    • Applications
    • WB, ELISA, FuncS

    Product Property

    • Purity
    • >95% as determined by analysis by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Buffer
    • PBS
    • Preservative
    • No preservatives
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Target

    • Alternative Names
    • ANGPT2; angiopoietin 2; ANG2; AGPT2; angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "Clone 5A12"

    See other products for "ANGPT2"

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    Please select product type
    IgG Antibody Products Single Domain Antibody Products Human Antibody Products Mouse Antibody Products Humanized Antibody Products Rabbit Monoclonal Antibody Products ScFv Antibody Products Fab Antibody Products ADCC Enhanced Antibody Products Antibody Magnetic Beads ScFv-Fc Chimera Products
    CAT Product Name Application Type
    DrMAB-973 Human Anti-ANGPT2 Recombinant Antibody (clone Angy-1-4) ELISA Human IgG2, λ
    HPAB-AP002-YC Human Anti-ANGPT2 Recombinant Antibody (clone MEDI1/5) ELISA, Inhib, FuncS Human IgG
    HPAB-AP003-YC Human Anti-ANGPT2 Recombinant Antibody (clone MEDI2/5) ELISA, Inhib, FuncS Human IgG
    HPAB-AP004-YC Human Anti-ANGPT2 Recombinant Antibody (clone MEDI3/5) ELISA, Inhib, FuncS Human IgG
    HPAB-AP005-YC Human Anti-ANGPT2 Recombinant Antibody (clone MEDI4/5) ELISA, Inhib, FuncS Human IgG

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    For Research Use Only. Not For Clinical Use.

    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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