Human Anti-ANGPT2 (clone MEDI1/5) scFv-Fc Chimera
CAT#: VS-0325-FY79
The anti-ANGPT2 scFv-Fc antibody targets angiopoietin-2 (ANGPT2), a key regulator of angiogenesis and vascular remodeling. It can modulate ANGPT2 signaling, potentially affecting vascular stability and permeability. The scFv-Fc format provides high specificity and prolonged half-life, enhancing its utility in research and therapeutic applications.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11437/27034_B_8_5.jpg
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human ANGPT2
- Species Reactivity
- Human
- Clone
- MEDI1/5
- Applications
- ELISA, Inhibition, Immunofluorescence
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Immunofluorescence: 2 μg/mL
Target
- Alternative Names
- Angiopoietin 2; ANG-2; Angiopoietin-2B; Angiopoietin-2a; Angiopoietin-2; Tie2-Ligand; AGPT2; ANG2
- Gene ID
- 285
- UniProt ID
- O15123
- Long Name
- Angiopoietin 2
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn89, Asn151, Asn119, Asn133, Asn240, and Asn304
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect ANGP2_HUMAN (664)
Glycosylation from GlyGen 7 sites, 23 N-linked glycans (4 sites), 1 O-linked glycan
- Protein Refseq
- NP_001112359.1; NP_001112360.1; NP_001138.1; NP_001373264.1; NP_001373265.1
- Function
- Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, 19116766, 19223473, 9204896).
Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1 (PubMed:15284220, 19116766, 19223473, 9204896).
In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "Clone MEDI1/5"
- CAT
- Product Name
See other products for "ANGPT2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-070 | Recombinant Anti-human ANGPT2 VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
| TAB-0032CL-VHH | Anti-Human ANGPT2 VHH Single Domain Antibody | ELISA, Block, SPR | Single domain antibody |
| TAB-0035CL-VHH | Anti-Human ANGPT2 VHH Single Domain Antibody | ELISA, Block, SPR | Single domain antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-077CT-S(P) | Anti-Human ANG2 Recombinant Antibody scFv Fragment (1A2) | ELISA, WB | Human antibody |
| TAB-077CT-F(E) | Anti-Human ANG2 Recombinant Antibody Fab Fragment (1A2) | ELISA, WB | Human antibody |
| TAB-0867CLV | Human Anti-ANGPT2 Recombinant Antibody (TAB-0867CLV) | ELISA | Human IgG |
| TAB-0869CLV | Human Anti-ANGPT2 Recombinant Antibody (TAB-0869CLV) | SPR, Inhib, FuncS | Human IgG |
| TAB-0870CLV | Human Anti-ANGPT2 Recombinant Antibody (TAB-0870CLV) | FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0886CLV | Human Anti-ANGPT2 Recombinant Antibody (TAB-0886CLV) | ELISA, WB | Humanized IgG1 |
| TAB-0887CLV | Human Anti-ANGPT2 Recombinant Antibody (TAB-0887CLV) | ELISA, WB | Humanized IgG1 |
| TAB-0888CLV | Human Anti-ANGPT2 Recombinant Antibody (TAB-0888CLV) | ELISA, WB | Humanized IgG1 |
| TAB-0889CLV | Human Anti-ANGPT2 Recombinant Antibody (TAB-0889CLV) | ELISA, WB | Humanized IgG1 |
| TAB-0890CLV | Human Anti-ANGPT2 Recombinant Antibody (TAB-0890CLV) | ELISA, WB | Humanized IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0894CLV | Mouse Anti-ANGPT2 Recombinant Antibody (TAB-0894CLV) | ELISA, WB | Mouse IgG |
| TAB-0895CLV | Mouse Anti-ANGPT2 Recombinant Antibody (TAB-0895CLV) | ELISA, WB | Mouse IgG |
| TAB-0896CLV | Mouse Anti-ANGPT2 Recombinant Antibody (TAB-0896CLV) | ELISA, WB | Mouse IgG |
| TAB-0897CLV | Mouse Anti-ANGPT2 Recombinant Antibody (TAB-0897CLV) | ELISA, WB | Mouse IgG |
| TAB-0894CLV-F(E) | Mouse Anti-ANGPT2 Recombinant Antibody; Fab Fragment (TAB-0894CLV-F(E)) | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0170 | Hi-Affi™ Rabbit Anti-ANGPT2 Recombinant Antibody (clone DS170AB) | IHC-Fr, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0111CQ | Human Anti-ANGPT2 Recombinant Antibody (HPAB-0111CQ) | ELISA, Neut, WB | Human IgG1, κ |
| HPAB-0112CQ | Human Anti-ANGPT2 Recombinant Antibody (HPAB-0112CQ) | ELISA, Neut, WB | Human IgG1, λ |
| HPAB-0172-WJ | Mouse Anti-ANGPT2 Recombinant Antibody (clone 10D6) | ELISA, IB, FuncS | Mouse IgG1, κ |
| HPAB-0479-WJ | Human Anti-ANGPT2 Recombinant Antibody (HPAB-0479-WJ) | ELISA | Human IgG |
| HPAB-0480-WJ | Human Anti-ANGPT2 Recombinant Antibody (HPAB-0480-WJ) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0111CQ-F(E) | Human Anti-ANGPT2 Recombinant Antibody; Fab Fragment (HPAB-0111CQ-F(E)) | ELISA, Neut, WB | Human Fab |
| HPAB-0112CQ-F(E) | Human Anti-ANGPT2 Recombinant Antibody; Fab Fragment (HPAB-0112CQ-F(E)) | ELISA, Neut, WB | Human Fab |
| HPAB-AP234-YC-F(E) | Human Anti-ANGPT2 Recombinant Antibody (HPAB-AP234-YC-F(E)); Fab Fragment | Block, FuncS | Human Fab |
| HPAB-AP235-YC-F(E) | Human Anti-ANGPT2 Recombinant Antibody (HPAB-AP235-YC-F(E)); Fab Fragment | Block, FuncS | Human Fab |
| HPAB-AP236-YC-F(E) | Human Anti-ANGPT2 Recombinant Antibody (HPAB-AP236-YC-F(E)); Fab Fragment | Block, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-461CQ | Afuco™ Anti-ANGPT2 Recombinant Antibody (AFC-TAB-461CQ), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP234-YC-S(P) | Human Anti-ANGPT2 Recombinant Antibody (HPAB-AP234-YC-S(P)); scFv Fragment | Block, FuncS | Human scFv |
| HPAB-AP235-YC-S(P) | Human Anti-ANGPT2 Recombinant Antibody (HPAB-AP235-YC-S(P)); scFv Fragment | Block, FuncS | Human scFv |
| HPAB-AP236-YC-S(P) | Human Anti-ANGPT2 Recombinant Antibody (HPAB-AP236-YC-S(P)); scFv Fragment | Block, FuncS | Human scFv |
| HPAB-AP237-YC-S(P) | Human Anti-ANGPT2 Recombinant Antibody (HPAB-AP237-YC-S(P)); scFv Fragment | Block, FuncS | Human scFv |
| HPAB-AP238-YC-S(P) | Human Anti-ANGPT2 Recombinant Antibody (HPAB-AP238-YC-S(P)); scFv Fragment | Block, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY12 | AbPlus™ Anti-ANGPT2 Magnetic Beads (VS-0424-XY12) | IP, Protein Purification | |
| VS-0724-YC1209 | AbPlus™ Anti-ANGPT2 Magnetic Beads (VS-0724-YC1209) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY367 | Anti-ANGPT2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY368 | Anti-Mouse ANGPT2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY369 | Anti-Rat ANGPT2 Immunohistochemistry Kit | IHC |
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