Recombinant Anti-human BMX Intrabody [(D-Arg)9]
CAT#: IAB-B077(A)
Recombinant anti-BMX intrabody linked to (D-Arg)9 works within cells to bind intracellur antigen BMX, expressed in 293T cells. These antibodiess bind specifically to recombinant BMX and efficiently block its kinase activity. When expressed in transformed cells, these antibodiess associated tightly with Etk, leading to significant blockade of Etk enzymatic activity and inhibition of clonogenic cell growth in soft agar.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HUVEC TERT2
Immunofluorescent staining of human cell line HUVEC TERT2 shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1048/1751_G2_18_cr58009842c82e5_selected.jpg
Normal Tissue
Figure 2 Epididymis
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1048/2306_A_1_6.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1048/2306_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1048/2306_A_9_3.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1048/2306_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (HUVEC TERT2)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000102010-BMX
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Specifications
- Immunogen
- human BMX non-receptor tyrosine kinase
- Host Species
- human
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Products can be used for: Coimmunopricipation; Functional studies
Product Property
- Purity
- >95% (SDS-PAGE)
- Storage
- Short Term Storage: 4°C
Long Term Storage: -20°C
Target
- Alternative Names
- BMX; BMX non-receptor tyrosine kinase; ETK; PSCTK2; PSCTK3; cytoplasmic tyrosine-protein kinase BMX; NTK38 tyrosine kinase; BTK-like on X chromosome; Etk/Bmx cytosolic tyrosine kinase; epithelial and endothelial tyrosine kinase; bone marrow tyrosine kinas
- Gene ID
- 660
- UniProt ID
- P51813
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "BMX"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B077(G) | Recombinant Anti-human BMX Intrabody [+36 GFP] | IF, ELISA, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B077(T) | Recombinant Anti-human BMX Intrabody [Tat] | FC, IF, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1504MZ | Mouse Anti-BMX Recombinant Antibody (clone 2D7) | ELISA, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0372 | Hi-Affi™ Rabbit Anti-BMX Recombinant Antibody (clone DS372AB) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0342F | Mouse Anti-Bmx Recombinant Antibody (ZG-0342F) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX126 | Mouse Anti-BMX Recombinant Antibody (clone 1C6) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS7-HM249 | Mouse Anti-BMX Recombinant Antibody (clone CBL083HM) | WB, ELISA | Mouse IgG |
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