Recombinant Anti-human BMX Intrabody [+36 GFP]

CAT#: IAB-B077(G)

Recombinant anti-BMX intrabody in fusion with +36GFP works within cells and specifically reacts with intracellur antigen BMX, expressed in 293T cells. These antibodiess bind specifically to recombinant BMX and efficiently block its kinase activity. When expressed in transformed cells, these antibodiess associated tightly with Etk, leading to significant blockade of Etk enzymatic activity and inhibition of clonogenic cell growth in soft agar.

Gene Expression
Figure 1 IF staining of human cell line HUVEC TERT2 Figure 2 Epididymis Figure 3 Cerebral cortex Figure 4 Colon Figure 5 Testis Figure 6 RNA cell line category: Cell line enriched (HUVEC TERT2)

Specifications

  • Immunogen
  • human BMX non-receptor tyrosine kinase
  • Host Species
  • human
  • Type
  • scFv-Tat
  • Cell Penetrating Peptide
  • TAT
    TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
  • Species Reactivity
  • human
  • Applications
  • Can be useful in applications such as: Immunofluorescence; Enzyme-linked Immunosorbent Assay; Functional studies

Product Property

  • Purity
  • >95% (SDS-PAGE)
  • Storage
  • Short Term Storage: 4°C
    Long Term Storage: -20°C

Target

  • Alternative Names
  • BMX; BMX non-receptor tyrosine kinase; ETK; PSCTK2; PSCTK3; cytoplasmic tyrosine-protein kinase BMX; NTK38 tyrosine kinase; BTK-like on X chromosome; Etk/Bmx cytosolic tyrosine kinase; epithelial and endothelial tyrosine kinase; bone marrow tyrosine kinas
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

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Protocol & Troubleshooting

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "BMX"

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CAT Product Name Application Type
IAB-B077(A) Recombinant Anti-human BMX Intrabody [(D-Arg)9] CO-IP, FuncS scFv-(D-Arg)9
IAB-B077(T) Recombinant Anti-human BMX Intrabody [Tat] FC, IF, FuncS scFv-Tat
CAT Product Name Application Type
MOR-0372 Hi-Affi™ Rabbit Anti-BMX Recombinant Antibody (clone DS372AB) WB, IP Rabbit IgG
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