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  • Recombinant Anti-human C12orf4 Intrabody [(D-Arg)9]

Recombinant Anti-human C12orf4 Intrabody [(D-Arg)9] (CAT#: IAB-B051(A))

Recombinant anti-C12orf4 intrabody linked to (D-Arg)9 works within cells and specifically reacts with protein C12orf4, expressed in E. cili cells. It has been showed an inhibition of mast cell activation and a decrease in allergic mediator release.


See more Engineered Antibody products for C12orf4
Specific Inquiry
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  • Purity:
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  • Gene Expression
  • Datasheet
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  • COA
Subcellular Location
Figure 1 IF staining of human cell line A-431
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nuclear bodies.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37871/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human kidney
Figure 2 IHC staining of human kidney
(Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37871/ihc_selected.jpg
Figure 3 Cerebral cortex
Figure 3 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37871/80715_B_8_5.jpg
Figure 4 Colon
Figure 4 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37871/80715_A_8_3.jpg
Figure 5 Liver
Figure 5 Liver
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37871/80715_A_8_5.jpg
Figure 6 Kidney
Figure 6 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37871/80715_A_8_5.jpg
Figure 7 Testis
Figure 7 Testis
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37871/80715_A_5_6.jpg
Figure 8 Lymph node
Figure 8 Lymph node
(Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37871/80715_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Figure 9 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000047621-C12orf4

Specifications

  • Immunogen
  • human chromosome 12 open reading frame 4
  • Host Species
  • human
  • Type
  • scFv-(D-Arg)9
  • Cell Penetrating Peptide
  • (D-Arg)9
    It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
  • Species Reactivity
  • human
  • Applications
  • Used for immunoassay techniques such as: Immunofluorescence; Flow Cytometry; Western blot; Functional studies

Product Property

  • Purity
  • >95% by HPLC
  • Storage
  • Store at -20°C for long-term storage. Store at 4°C for up to one month. Avoid freeze/thaw cycles.

Target

  • Alternative Names
  • C12ORF4; chromosome 12 open reading frame 4; uncharacterized protein C12orf4

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "C12orf4"

Intrabody

CAT Product Name Application Type
IAB-B051(G) Recombinant Anti-human C12orf4 Intrabody [+36 GFP] WB, CO-IP, FuncS scFv-(+36GFP)
IAB-B051(T) Recombinant Anti-human C12orf4 Intrabody [Tat] IF, ELISA, FuncS scFv-Tat

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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