Recombinant Anti-human C12orf4 Intrabody [Tat] (CAT#: IAB-B051(T))

Recombinant anti-C12orf4 intrabody in fusion with HIV Tat works within cells to bind protein C12orf4, expressed in E. cili cells. It has been showed an inhibition of mast cell activation and a decrease in allergic mediator release.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Immunogen
  • human chromosome 12 open reading frame 4
  • Host Species
  • human
  • Type
  • scFv-Tat
  • Cell Penetrating Peptide
  • TAT
    TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
  • Species Reactivity
  • human
  • Applications
  • Can be useful in applications such as: Immunofluorescence; Enzyme-linked Immunosorbent Assay; Functional studies

Product Property

  • Purity
  • >98% by SDS-PAGE and HPLC analysis
  • Storage
  • Short Term Storage: 4°C
    Long Term Storage: -20°C

Target

  • Alternative Names
  • C12ORF4; chromosome 12 open reading frame 4; uncharacterized protein C12orf4

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "C12orf4"

Intrabody

CAT Product Name Application Type
IAB-B051(A) Recombinant Anti-human C12orf4 Intrabody [(D-Arg)9] IF, FC, WB, FuncS scFv-(D-Arg)9
IAB-B051(G) Recombinant Anti-human C12orf4 Intrabody [+36 GFP] WB, CO-IP, FuncS scFv-(+36GFP)

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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