Anti-Human C3b Recombinant Antibody (9556) (CAT#: TAB-1365CL)

This antibody that specifically binds to a human or cynomolgus complement C3b protein can be used to inhibit the alternative complement pathway.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Datasheet
  • MSDS
  • COA

Figure 1 The C3b antibodies bind to C3b with at least 1000 fold higher selectivity relative to C3.

Figure 1 The C3b antibodies bind to C3b with at least 1000 fold higher selectivity relative to C3.

Inhib

Figure 2 The ability of the C3b antibodies to inhibit production of C3b as a breakdown product of C3.

Figure 2 The ability of the C3b antibodies to inhibit production of C3b as a breakdown product of C3.

Inhib

Figure 3 The ability of the C3b antibodies to inhibit the deposition of MAC.

Figure 3 The ability of the C3b antibodies to inhibit the deposition of MAC.

Inhib

Figure 4 The C3b antibodies block alternative pathway-driven complement activation by inhibiting generation of C3a and C5a.

Figure 4 The C3b antibodies block alternative pathway-driven complement activation by inhibiting generation of C3a and C5a.

Inhib

Figure 5 SDS-PAGE gel showing the inhibition of tick-over convertase enzyme activity. B shows the quantitation of inhibition of C3b generation in the gel in A. C shows that anti-C3b antibodies inhibit pre-formed C3 convertase enzyme activity.

Figure 5 SDS-PAGE gel showing the inhibition of tick-over convertase enzyme activity. B shows the quantitation of inhibition of C3b generation in the gel in A. C shows that anti-C3b antibodies inhibit pre-formed C3 convertase enzyme activity.

Inhib

Figure 6 The anti-C3b antibodies inhibit in vitro C5 convertase enzyme activity.

Figure 6 The anti-C3b antibodies inhibit in vitro C5 convertase enzyme activity.

Inhib

Figure 7 A shows the inhibition of Factor B binding to C3b by C3b antibodies. B shows inhibition of factor P binding to C3b by C3b antibodies. C shows inhibition of factor H binding to C3b by C3b antibodies. D shows inhibition of C3b-C3b dimer formation by C3b antibodies.

Figure 7 A shows the inhibition of Factor B binding to C3b by C3b antibodies. B shows inhibition of factor P binding to C3b by C3b antibodies. C shows inhibition of factor H binding to C3b by C3b antibodies. D shows inhibition of C3b-C3b dimer formation by C3b antibodies.

ELISA

Figure 8 The results of an antibody cross reactivity assay against C3d.

Figure 8 The results of an antibody cross reactivity assay against C3d.

ELISA

Figure 9 The results of an antibody cross reactivity assay against C5.

Figure 9 The results of an antibody cross reactivity assay against C5.

ELISA

Figure 10 The results from binding assays performed to determine whether the C3b antibodies bind to iC3b or C3c.

Figure 10 The results from binding assays performed to determine whether the C3b antibodies bind to iC3b or C3c.


Specifications

  • Host Species
  • Human
  • Type
  • Fully human antibody
  • Specificity
  • Human
  • Species Reactivity
  • Cynomolgus complement protein C3b
  • Clone
  • 9556
  • Applications
  • ELISA, Inhib
  • Related Disease
  • Disorders associated with activation of the complement pathway include nephritis, asthma, reperfusion injury, hemodialysis, rheumatoid arthritis, systemic lupus, psoriasis, multiple sclerosis, transplantation, Alzheimer's disease, aHUS, MPGN II, or any other complement-mediated disease.

Applications

  • Application Notes
  • This antibody has been tested for use in Enzyme-linked Immunosorbent Assay and Inhibition.

Target

  • Alternative Names
  • C3b; complement component 3b

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 9556"

See other products for "C3b"

Human Antibody

CAT Product Name Application Type
TAB-1365CL-S(P) Anti-Human C3b Recombinant Antibody scFv Fragment (9556) ELISA, Inhib Fully human antibody
TAB-1365CL-F(E) Anti-Human C3b Recombinant Antibody Fab Fragment (9556) ELISA, Inhib Fully human antibody

Recombinant Antibody

CAT Product Name Application Type
HPAB-AP270-YC Human Anti-C3b Recombinant Antibody (HPAB-AP270-YC) ELISA, Inhib Chimeric (mouse/human) IgG
HPAB-AP271-YC Human Anti-C3b Recombinant Antibody (HPAB-AP271-YC) ELISA, Inhib Humanized (mouse/human) IgG
HPAB-AP272-YC Human Anti-C3b Recombinant Antibody (HPAB-AP272-YC) ELISA, Inhib Humanized (mouse/human) IgG
HPAB-AP273-YC Human Anti-C3b Recombinant Antibody (HPAB-AP273-YC) ELISA, Inhib Humanized (mouse/human) IgG
HPAB-AP274-YC Mouse Anti-C3b Recombinant Antibody (HPAB-AP274-YC) ELISA, Inhib Mouse IgG

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for TAB-1365CL. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare