Anti-Human C3b Recombinant Antibody (9556) (CAT#: TAB-1365CL)

Figure 1 The C3b antibodies bind to C3b with at least 1000 fold higher selectivity relative to C3.

Figure 2 The ability of the C3b antibodies to inhibit production of C3b as a breakdown product of C3.

Figure 3 The ability of the C3b antibodies to inhibit the deposition of MAC.

Figure 4 The C3b antibodies block alternative pathway-driven complement activation by inhibiting generation of C3a and C5a.

Figure 5 SDS-PAGE gel showing the inhibition of tick-over convertase enzyme activity. B shows the quantitation of inhibition of C3b generation in the gel in A. C shows that anti-C3b antibodies inhibit pre-formed C3 convertase enzyme activity.

Figure 6 The anti-C3b antibodies inhibit in vitro C5 convertase enzyme activity.

Figure 7 A shows the inhibition of Factor B binding to C3b by C3b antibodies. B shows inhibition of factor P binding to C3b by C3b antibodies. C shows inhibition of factor H binding to C3b by C3b antibodies. D shows inhibition of C3b-C3b dimer formation by C3b antibodies.

Figure 8 The results of an antibody cross reactivity assay against C3d.

Figure 9 The results of an antibody cross reactivity assay against C5.

Figure 10 The results from binding assays performed to determine whether the C3b antibodies bind to iC3b or C3c.