Anti-Human C3b Recombinant Antibody (9556) (CAT#: TAB-1365CL)
This antibody that specifically binds to a human or cynomolgus complement C3b protein can be used to inhibit the alternative complement pathway.
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Figure 1 The C3b antibodies bind to C3b with at least 1000 fold higher selectivity relative to C3.
Inhib
Figure 2 The ability of the C3b antibodies to inhibit production of C3b as a breakdown product of C3.
Inhib
Figure 3 The ability of the C3b antibodies to inhibit the deposition of MAC.
Inhib
Figure 4 The C3b antibodies block alternative pathway-driven complement activation by inhibiting generation of C3a and C5a.
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Figure 5 SDS-PAGE gel showing the inhibition of tick-over convertase enzyme activity. B shows the quantitation of inhibition of C3b generation in the gel in A. C shows that anti-C3b antibodies inhibit pre-formed C3 convertase enzyme activity.
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Figure 6 The anti-C3b antibodies inhibit in vitro C5 convertase enzyme activity.
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Figure 7 A shows the inhibition of Factor B binding to C3b by C3b antibodies. B shows inhibition of factor P binding to C3b by C3b antibodies. C shows inhibition of factor H binding to C3b by C3b antibodies. D shows inhibition of C3b-C3b dimer formation by C3b antibodies.
ELISA
Figure 8 The results of an antibody cross reactivity assay against C3d.
ELISA
Figure 9 The results of an antibody cross reactivity assay against C5.
ELISA
Figure 10 The results from binding assays performed to determine whether the C3b antibodies bind to iC3b or C3c.
Specifications
- Host Species
- Human
- Type
- Fully human antibody
- Specificity
- Human
- Species Reactivity
- Cynomolgus complement protein C3b
- Clone
- 9556
- Applications
- ELISA, Inhib
- Related Disease
- Disorders associated with activation of the complement pathway include nephritis, asthma, reperfusion injury, hemodialysis, rheumatoid arthritis, systemic lupus, psoriasis, multiple sclerosis, transplantation, Alzheimer's disease, aHUS, MPGN II, or any other complement-mediated disease.
Applications
- Application Notes
- This antibody has been tested for use in Enzyme-linked Immunosorbent Assay and Inhibition.
Target
- Alternative Names
- C3b; complement component 3b
Related Resources
Systemic Lupus Erythematosus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Human Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-420 | Human Anti-C3b Recombinant Antibody (clone S77) | FuncS, Inhib, IP, ELISA | Human IgG |
| HPAB-671-FY | Human Anti-C3b Recombinant Antibody (clone MOR9612) | ELISA | Human IgG |
| HPAB-AP270-YC | Human Anti-C3b Recombinant Antibody (HPAB-AP270-YC) | ELISA, Inhib | Chimeric (mouse/human) IgG |
| HPAB-AP271-YC | Human Anti-C3b Recombinant Antibody (HPAB-AP271-YC) | ELISA, Inhib | Humanized (mouse/human) IgG |
| HPAB-AP272-YC | Human Anti-C3b Recombinant Antibody (HPAB-AP272-YC) | ELISA, Inhib | Humanized (mouse/human) IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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