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    Recombinant Anti-human CCNT1 Intrabody [+36 GFP] (CAT#: IAB-B032(G))

    Recombinant anti-CCNT1 intrabody in fusion with +36GFP works within cells to bind human CCNT1, expressed in 293T cells. Anti-hCyclinT1 intrabodies can be designed to block HIV-1 replication without causing cellular toxicity, and as a result, they may be useful agents for "intracellular immunization"-based gene therapy strategies for HIV-1 infection/AIDS.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-251 MG
    Figure 1 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4892/if_selected.jpg
    Figure 2 IF staining of human cell line SiHa
    Figure 2 IF staining of human cell line SiHa
    (Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/72012/1859_D8_31_selected.jpg
    Figure 3 IF staining of human cell line U-2 OS
    Figure 3 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/9016/if_selected.jpg
    Normal Tissue
    Figure 4 IHC staining of human tonsil
    Figure 4 IHC staining of human tonsil
    (Immunohistochemical staining of human tonsil shows strong nuclear positivity in germinal center cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/9016/27576_A_5_8_selected.jpg
    Figure 5 Lymph node
    Figure 5 Lymph node
    (Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4892/16364_A_8_8.jpg
    Figure 6 Cerebral cortex
    Figure 6 Cerebral cortex
    (Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4892/16364_B_7_5.jpg
    Figure 7 Colon
    Figure 7 Colon
    (Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4892/16364_A_8_3.jpg
    Figure 8 Kidney
    Figure 8 Kidney
    (Bowman's capsule Staining: Low Intensity: Moderate Quantity: <25% Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Collecting ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4892/16364_A_7_5.jpg
    Figure 9 Testis
    Figure 9 Testis
    (Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Round or early spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4892/16364_A_6_6.jpg
    RNA Expression
    Figure 10 RNA cell line category: Low cell line specificity
    Figure 10 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000129315-CCNT1

    Specifications

    • Immunogen
    • human cyclin T1
    • Host Species
    • human
    • Type
    • scFv-(+36GFP)
    • Cell Penetrating Peptide
    • +36 GFP
      GFP with a theoretical net charge of +36 (+36 GFP) penetrated several different mammalian cell lines at very low (nanomolar) concentrations. Cationic peptides and proteins have been observed to penetrate cells, and both natural and synthetic cell-penetrating peptides are widely used as delivery vehicles. However, whereas a covalent link between the cell-penetrating peptide and its cargo is typically required.
    • Species Reactivity
    • human
    • Applications
    • Products can be used for: Fluorescence-activated cell sorting; Immunocytochemistry; Functional studies

    Product Property

    • Purity
    • >90% assessed by SDS-PAGE
    • Storage
    • Short term: store at 4°C (over 6 months), long term: -20°C or -80°C.

    Target

    • Alternative Names
    • CCNT1; cyclin T1; CCNT; CYCT1; HIVE1; cyclin-T1; cyclin C-related protein; CDK9-associated C-type protein; human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

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    See other products for "CCNT1"

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    Please select product type
    Intrabody Products IgG Antibody Products Non-Human Primate (NHP) Antibody Products
    CAT Product Name Application Type
    IAB-B032(A) Recombinant Anti-human CCNT1 Intrabody [(D-Arg)9] FACS, ELISA, IF, FuncS scFv-(D-Arg)9
    IAB-B032(T) Recombinant Anti-human CCNT1 Intrabody [Tat] ELISA, ICC, FuncS scFv-Tat

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