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CCNT1
CCNT1 (Cyclin T1) is a Protein Coding gene. Diseases associated with CCNT1 include Human Immunodeficiency Virus Type 1. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and Gene Expression. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription regulatory region DNA binding. An important paralog of this gene is CCNT2.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Cyclin-T1 is the predominant cyclin that associates with CDK9 to form a heterodimer called P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31. Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin (PubMed:10393184). Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs (PubMed:17643375). Interacts with BRD4, targets chromatin binding (PubMed:16109376, PubMed:16109377, PubMed:24360279). Interacts with JMJD6 (PubMed:24360279). Interacts with MDFIC (PubMed:12944466). Interacts with HSF1 (PubMed:27189267). Interacts with HTATSF1 (PubMed:10913173). Interacts with AFF4 (PubMed:12065898). Interacts with TBX21 (PubMed:27292648). (Microbial infection) Interacts with the transactivation region of HIV-1, HIV-2 and SIV Tat.
Molecular function
Cyclin
More Types Infomation
- Recombinant Anti-human CCNT1 Intrabody [Tat] (IAB-B032(T))
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- Species Reactivity: human
- Type: scFv-Tat
- Application: ELISA, ICC, FuncS
- Recombinant Anti-human CCNT1 Intrabody [+36 GFP] (IAB-B032(G))
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- Species Reactivity: human
- Type: scFv-(+36GFP)
- Application: FACS, ICC, FuncS
- Recombinant Anti-human CCNT1 Intrabody [(D-Arg)9] (IAB-B032(A))
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- Species Reactivity: human
- Type: scFv-(D-Arg)9
- Application: FACS, ELISA, IF, FuncS
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-F, IHC-P, ICC, IF, IP
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For Research Use Only. Not For Clinical Use.