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    Recombinant Anti-human CCNT1 Intrabody [Tat] (CAT#: IAB-B032(T))

    Recombinant anti-CCNT1 intrabody in fusion with HIV Tat works within cells to bind human CCNT1, expressed in 293T cells. Anti-hCyclinT1 intrabodies can be designed to block HIV-1 replication without causing cellular toxicity, and as a result, they may be useful agents for "intracellular immunization"-based gene therapy strategies for HIV-1 infection/AIDS.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-251 MG
    Figure 1 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4892/if_selected.jpg
    Figure 2 IF staining of human cell line SiHa
    Figure 2 IF staining of human cell line SiHa
    (Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/72012/1859_D8_31_selected.jpg
    Figure 3 IF staining of human cell line U-2 OS
    Figure 3 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/9016/if_selected.jpg
    Normal Tissue
    Figure 4 IHC staining of human tonsil
    Figure 4 IHC staining of human tonsil
    (Immunohistochemical staining of human tonsil shows strong nuclear positivity in germinal center cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/9016/27576_A_5_8_selected.jpg
    Figure 5 Lymph node
    Figure 5 Lymph node
    (Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4892/16364_A_8_8.jpg
    Figure 6 Cerebral cortex
    Figure 6 Cerebral cortex
    (Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4892/16364_B_7_5.jpg
    Figure 7 Colon
    Figure 7 Colon
    (Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4892/16364_A_8_3.jpg
    Figure 8 Kidney
    Figure 8 Kidney
    (Bowman's capsule Staining: Low Intensity: Moderate Quantity: <25% Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Collecting ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4892/16364_A_7_5.jpg
    Figure 9 Testis
    Figure 9 Testis
    (Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Round or early spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4892/16364_A_6_6.jpg
    RNA Expression
    Figure 10 RNA cell line category: Low cell line specificity
    Figure 10 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000129315-CCNT1

    Specifications

    • Immunogen
    • human cyclin T1
    • Host Species
    • human
    • Type
    • scFv-Tat
    • Cell Penetrating Peptide
    • TAT
      TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
    • Species Reactivity
    • human
    • Applications
    • Can be useful in applications such as: Enzyme-linked Immunosorbent Assay; Immunocytochemistry; Functional studies

    Product Property

    • Purity
    • >95%, by SDS-PAGE with Coomassie Brilliant Blue staining
    • Storage
    • Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Target

    • Alternative Names
    • CCNT1; cyclin T1; CCNT; CYCT1; HIVE1; cyclin-T1; cyclin C-related protein; CDK9-associated C-type protein; human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

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    See other products for "CCNT1"

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    Please select product type
    Intrabody Products IgG Antibody Products Non-Human Primate (NHP) Antibody Products
    CAT Product Name Application Type
    IAB-B032(A) Recombinant Anti-human CCNT1 Intrabody [(D-Arg)9] FACS, ELISA, IF, FuncS scFv-(D-Arg)9
    IAB-B032(G) Recombinant Anti-human CCNT1 Intrabody [+36 GFP] FACS, ICC, FuncS scFv-(+36GFP)

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