Anti-Human CD34 Recombinant Antibody Fab Fragment (h4C8)
CAT#: TAB-149LC-F(E)
TAB-149LC is a recombinant humanized antibody, which targets CD34. It has a strong affinity for highly-expressed CD34 on human myeloid leukemia cells. By attaching it to magnetic nano materials, it can be used to create immunomagnetic beads for sorting marrow hemopoietic stem cells. This antibody has the ability to significantly reduce the incidence of HAMA, making clinical hematopoietic stem cell transplantation safer. It is primarily used in the treatment of specific malignant blood diseases and solid tumors. TAB-149LC-F(E) antibody is the Fab fragment antibody form of TAB-149LC antibody. Fab fragments, the antigen-binding domains of an antibody molecule, consist of two amino acid chains composed of VH+CH1 and VL+CL domains.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line HUVEC TERT2 shows localization to nucleoplasm & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36723/1751_G1_7_cr57fd220c70be0_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18/155469_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18/155469_A_9_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18/155469_A_8_5.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (HUVEC TERT2, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000174059-CD34
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Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- h4C8
- Applications
- ELISA
- Related Disease
- Malignant blood diseasesm, Solid tumors
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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|---|---|---|---|
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| HPAB-M0472-YC-F(E) | Mouse Anti-CD34 Recombinant Antibody; Fab Fragment (HPAB-M0472-YC-F(E)) | WB, IF, IHC, IP, WB | Mouse Fab |
| HPAB-M0473-YC-F(E) | Human Anti-CD34 Recombinant Antibody; Fab Fragment (HPAB-M0473-YC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| HPAB-M0474-YC-F(E) | Human Anti-CD34 Recombinant Antibody; Fab Fragment (HPAB-M0474-YC-F(E)) | ELISA | Humanized Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-175-S(P) | Recombinant Human Anti-human CD34 Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| HPAB-M0472-YC-S(P) | Mouse Anti-CD34 Recombinant Antibody; scFv Fragment (HPAB-M0472-YC-S(P)) | WB, IF, IHC, IP, WB | Mouse scFv |
| HPAB-M0473-YC-S(P) | Human Anti-CD34 Recombinant Antibody; scFv Fragment (HPAB-M0473-YC-S(P)) | ELISA | Mouse scFv |
| HPAB-0883-WJ-S(P) | Mouse Anti-CD34 Recombinant Antibody; scFv Fragment (HPAB-0883-WJ-S(P)) | ELISA | Mouse scFv |
| HPAB-0884-WJ-S(P) | Human Anti-CD34 Recombinant Antibody; scFv Fragment (HPAB-0884-WJ-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-149LC | Anti-Human CD34 Recombinant Antibody (h4C8) | FC, Inhib | Humanized antibody |
| TAB-149LC-S(P) | Anti-Human CD34 Recombinant Antibody scFv Fragment (h4C8) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-150LC | Human Anti-CD34 Recombinant Antibody (TAB-150LC) | ELISA | Human IgG |
| TAB-150LC-S(P) | Human Anti-CD34 Recombinant Antibody; scFv Fragment (TAB-150LC-S(P)) | ELISA | Human scFv |
| TAB-150LC-F(E) | Human Anti-CD34 Recombinant Antibody; Fab Fragment (TAB-150LC-F(E)) | ELISA | Human Fab |
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-0525-XY1164 | Anti-Mouse CD34 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1161 | Anti-Human CD34 Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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