Anti-CD72 immunotoxin J3-109 (IgG)-PAP (CAT#: AGTO-G083P)
This immunotoxin was achieved by conjugating/fusing the Anti-CD72 monoclonal antibody to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of acute lymphoblastic leukemias (ALL).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SH-SY5Y
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/44658/1373_H2_4_selected.jpg
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/44658/1373_H2_4_selected.jpg
Figure 2 Spleen
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/ihc_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/ihc_selected.jpg
Figure 3 Bone marrow
(Hematopoietic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/6524_B_5_4.jpg
(Hematopoietic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/6524_B_5_4.jpg
Figure 4 High expression in lymph node
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/6524_A_9_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/6524_A_9_8.jpg
Figure 5 RNA cell line category: Cell line enhanced (Daudi, Karpas-707, REH, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000137101-CD72
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000137101-CD72
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- J3-109
- Molecule Class
- IgG-PAP
- Toxin Description
- Pokeweed antiviral protein (PAP) is a type I ribosome inactivating protein isolated from the pokeweed plant, Phytolacca americana. The toxin is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Acute lymphoblastic leukemias (ALL)
Target
- Alternative Names
- CD72; CD72 molecule; LYB2; CD72b; B-cell differentiation antigen CD72; lyb-2; CD72 antigen; Pokeweed Antiviral Protein; Pokeweed; PAP
- Gene ID
- 971
- UniProt ID
- P21854
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0273MC | Human Anti-CD72 Recombinant Antibody (clone YC015) | ELISA, WB, FuncS | |
| MOB-0274MC | Human Anti-CD72 Recombinant Antibody (clone YC016); scFv Fragment | ELISA, WB, FuncS | Human scFv |
| HPAB-0062CQ | Human Anti-CD72 Recombinant Antibody (clone sc02-004) | IHC | Human IgG1, κ |
| HPAB-0063CQ | Human Anti-CD72 Recombinant Antibody (clone sc02-025) | IHC | Human IgG1, λ |
| HPAB-2053-FY | Human Anti-CD72 Recombinant Antibody (clone II-2) | FC | Human IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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