Anti-CD72 immunotoxin J3-109 (IgG)-PAP (AGTO-G083P)
This immunotoxin was achieved by conjugating/fusing the Anti-CD72 monoclonal antibody to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of acute lymphoblastic leukemias (ALL).
Specifications
- Host
- Mouse
- Species Reactivity
- Human
- Clone
- J3-109
- Molecule Class
- IgG-PAP
- Toxin Description
- Pokeweed antiviral protein (PAP) is a type I ribosome inactivating protein isolated from the pokeweed plant, Phytolacca americana. The toxin is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Acute lymphoblastic leukemias (ALL)
Target
- Alternative Names
- CD72; CD72 molecule; LYB2; CD72b; B-cell differentiation antigen CD72; lyb-2; CD72 antigen; Pokeweed Antiviral Protein
- Entrez Gene ID
- 971
- UniProt ID
- P21854
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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