Anti-CD72 immunotoxin J3-109 (IgG)-PAP
CAT#: AGTO-G083P
This immunotoxin was achieved by conjugating/fusing the Anti-CD72 monoclonal antibody to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of acute lymphoblastic leukemias (ALL).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/44658/1373_H2_4_selected.jpg
Normal Tissue
Figure 2 Spleen
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/ihc_selected.jpg
Normal Tissue
Figure 3 Bone marrow
Hematopoietic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/6524_B_5_4.jpg
Normal Tissue
Figure 4 High expression in lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2505/6524_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Daudi, Karpas-707, REH, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000137101-CD72
❮
❯
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- J3-109
- Molecule Class
- IgG-PAP
- Toxin Description
- Pokeweed antiviral protein (PAP) is a type I ribosome inactivating protein isolated from the pokeweed plant, Phytolacca americana. The toxin is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Acute lymphoblastic leukemias (ALL)
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for AGTO-G083P. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone J3-109"
- CAT
- Product Name
See other products for "CD72"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0273MC | Human Anti-CD72 Recombinant Antibody (clone YC015) | ELISA, WB, FuncS | |
| MOB-0274MC | Human Anti-CD72 Recombinant Antibody (clone YC016); scFv Fragment | ELISA, WB, FuncS | Human scFv |
| MOB-1640MZ | Recombinant Mouse Anti-Human CD72 Antibody (clone 4G4) | FC, IP | Mouse antibody |
| HPAB-0062CQ | Human Anti-CD72 Recombinant Antibody (clone sc02-004) | IHC | Human IgG1, κ |
| HPAB-0063CQ | Human Anti-CD72 Recombinant Antibody (clone sc02-025) | IHC | Human IgG1, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0578 | Hi-Affi™ Rabbit Anti-CD72 Recombinant Antibody (clone DS578AB) | ICC, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0062CQ-S(P) | Human Anti-CD72 Recombinant Antibody (clone sc02-004); scFv Fragment | IHC | Human scFv |
| HPAB-0063CQ-S(P) | Human Anti-CD72 Recombinant Antibody (clone sc02-025); scFv Fragment | IHC | Human scFv |
| HPAB-2053-FY-S(P) | Human Anti-CD72 Recombinant Antibody (clone II-2); scFv Fragment | FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0062CQ-F(E) | Human Anti-CD72 Recombinant Antibody (clone sc02-004); Fab Fragment | IHC | Human Fab |
| HPAB-0063CQ-F(E) | Human Anti-CD72 Recombinant Antibody (clone sc02-025); Fab fragment | IHC | Human Fab |
| HPAB-2053-FY-F(E) | Human Anti-CD72 Recombinant Antibody (clone II-2); Fab Fragment | FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC506 | Recombinant Anti-CD72 Vesicular Antibody, EV Displayed (VS-0425-YC506) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1216 | Anti-CD72 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: ELISA, SPR, Inhib, FuncS
-YJ-3.jpg)
Application: ELISA
-2.png)
Application: WB, ELISA, FC, IHC, IP
Application: WB, ELISA, IF
Application: Neut, ELISA, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
-3.jpg)
Application: Neut
Application: ELISA, FC, Neut, Inhib
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
