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CD72
CD72 (Cluster of Differentiation 72), also known in murine biology as Lyb-2, is a protein active in the immune system of animals. It consists of two identical halves, each of about 39-43 kD, and is a C-type lectin. Its primarily locus of expression is B-cells, where it appears to mediate aspects of B-cell - T-cell interaction. It is a ligand for CD5
Protein class
CD markers
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (B-cells, Kupffer cells, Macrophages, NK-cells, Hofbauer cells, dendritic cells)
Immune cell specificity
Group enriched (naive B-cell, memory B-cell)
Cell line specificity
Cell line enhanced (Daudi, Karpas-707, REH, U-698)
Interaction
Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1 (By similarity).
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: FC, IP
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB, FuncS
- Human Anti-CD72 Recombinant Antibody (clone YC015) (MOB-0273MC)
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- Species Reactivity: Human
- Application: ELISA, WB, FuncS
- Human Anti-CD72 Recombinant Antibody (clone BU40) (FAMAB-1080CQ)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: WB, FC, Apop
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, FC, IHC, IP
- Mouse Anti-CD72 Antibody (clone J3-109), mRNA (AGTO-G083P-mRNA)
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- Species Reactivity: Human
- Anti-CD72 (clone 10D6.8.1)-mc-MMAF ADC (ADC-180LZY)
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- Target: CD72
- Linker: mc (maleimidocaproyl)
- Drug: MMAF (monomethyl auristatin F)
- Human Anti-CD72 Recombinant Antibody (clone sc02-025); Fab fragment (HPAB-0063CQ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: IHC
- Human Anti-CD72 Recombinant Antibody (clone sc02-004); Fab Fragment (HPAB-0062CQ-F(E))
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human Fab
- Application: IHC
- Human Anti-CD72 Recombinant Antibody (clone II-2); scFv Fragment (HPAB-2053-FY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FC
- Human Anti-CD72 Recombinant Antibody (clone II-2); Fab Fragment (HPAB-2053-FY-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: FC
- Human Anti-CD72 Recombinant Antibody (clone II-2) (HPAB-2053-FY)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: FC
- Human Anti-CD72 Recombinant Antibody (clone sc02-025); scFv Fragment (HPAB-0063CQ-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: IHC
- Human Anti-CD72 Recombinant Antibody (clone sc02-004); scFv Fragment (HPAB-0062CQ-S(P))
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human scFv
- Application: IHC
- Human Anti-CD72 Recombinant Antibody (clone sc02-025) (HPAB-0063CQ)
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- Species Reactivity: Human
- Type: Human IgG1, λ
- Application: IHC
- Human Anti-CD72 Recombinant Antibody (clone sc02-004) (HPAB-0062CQ)
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Human IgG1, κ
- Application: IHC
- Anti-CD72 (clone 10D6.8.1)-mc-vc-PABC-MMAE ADC (ADC-179LZY)
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- Target: CD72
- Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
- Drug: MMAE (monomethyl auristatin E)
- Anti-CD72 (clone 10D6.8.1)-MCC-DM1 ADC (ADC-178LZY)
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- Target: CD72
- Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
- Anti-CD72 (clone 10D6.8.1)-SPP-DM1 ADC (ADC-177LZY)
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- Target: CD72
- Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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For Research Use Only. Not For Clinical Use.