Afuco™ Anti-Human CLDN18 ADCC Recombinant Antibody, ADCC Enhanced (AFC-158CL) (CAT#: AFC-158CL)
Anti-CLDN18 ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. This antibody is a monoclonal antibody specific for gastric and gastroesophageal adenocarcinomas. Preclinically, This antibody was shown to inhibit tumor growth and to kill cancer cells by indirect (complement-dependent cytoxicity, antibody-dependent cellular cytotoxicity) and direct mechanisms (antiproliferative and proapoptotic effects).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line OE19
(Immunofluorescent staining of human cell line OE19 shows localization to cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18446/1971_G5_3_selected.jpg
(Immunofluorescent staining of human cell line OE19 shows localization to cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18446/1971_G5_3_selected.jpg
Figure 2 IHC staining of human stomach
(Immunohistochemical staining of human stomach shows strong membranous and cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13010/ihc_selected.jpg
(Immunohistochemical staining of human stomach shows strong membranous and cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13010/ihc_selected.jpg
Figure 3 Stomach
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13243/28279_A_2_1.jpg
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13243/28279_A_2_1.jpg
Figure 4 RNA cell line category: Cell line enriched (OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000066405-CLDN18
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000066405-CLDN18
Specifications
- Host Species
- Chimeric undefined source
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Gastric Cancer
Product Property
- Purity
- 95% by HPLC
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Target
- Alternative Names
- CLDN18; claudin 18; SFTA5; SFTPJ; claudin-18; surfactant associated 5; surfactant associated protein J; surfactant, pulmonary associated protein J
- Gene ID
- 51208
- UniProt ID
- P56856
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-215-F(E) | Recombinant Anti-human CLDN18 Antibody Fab Fragment | IP, IF, FuncS | Fab |
| MHH-215-F(E) | Recombinant Human Anti-human CLDN18 Antibody Fab Fragment | WB, IF, FuncS | Fab |
Customer Reviews and Q&As
Customer Review
Q&As
Low Non-Specific Binding
One of the best features of this antibody is its minimal non-specific binding. It provides clear and accurate results in both immunofluorescence and Western blotting, which is critical for precise data interpretation.
High Purity & Quality
The antibody's purification quality is outstanding. High purity enhances our assays' performance, yielding reliable and reproducible results every time.
Superior Technical Support
Though we encountered some initial issues, the technical support was prompt and effective. They provided insightful advice and practical solutions that helped us achieve optimal results. Excellent customer service.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# AFC-158CL, RRID: AB_3111276)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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