This immunotoxin was achieved by conjugating/fusing the Anti-EEF2 scFv to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to leukemia cells and the toxin enters cells by receptor-mediated endocytosis. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death. It was designed for treatment of T cell leukemia.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-2641z | Mouse Anti-EEF2 Recombinant Antibody (clone 26G3) | WB, ELISA, ICC, IF, IHC | Mouse IgG1 |
MOB-2361MZ | Recombinant Mouse Anti-Human EEF2 Antibody (clone FMM3B22I3) | WB | Mouse antibody |
ZG-0271J | Mouse Anti-EEF2 Recombinant Antibody (ZG-0271J) | WB, ICC | Mouse IgG |
VS3-WK160 | Mouse Anti-EEF2 Recombinant Antibody (clone H1-B6) | WB, ELISA | Mouse IgG1 |
VS4-WK153 | Mouse Anti-EEF2 Recombinant Antibody (VS4-WK153) | ELISA, WB | Mouse IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G017E | Anti-EEF2 immunotoxin G4S (scFv)-PE | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1096 | Hi-Affi™ Rabbit Anti-EEF2 Recombinant Antibody (clone DS1096AB) | WB, IHC-P, ICC, IF | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC1929 | PE-A*02:01/Human EEF2 (ILTDITKGV) MHC Tetramer | FCM | |
MHC-LC4409 | PE-A*01:01/Human EEF2 (YFDPANGKF) MHC Tetramer | FCM |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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