Anti-Mouse Emb Recombinant Antibody (3E66) (CAT#: TAB-331MZ)

Figure 1 is a figure shows evaluation of a binding activity of an anti-Embigin antibody to mouse Embigin expressing rat cells and rat cells by flow cytometry.

Isotype (rat IgG) relative to the anti-Embigin antibody was 5 μg/mL concentration, and a culture supernatant was used as the anti-Embigin antibody (anti-emb antibody).

Figure 2 is a figure shows evaluation of cell depletion specificity of a toxin-modified anti-Embigin antibody in pathogenic cells.

Figure 3 is a figure shows evaluation of the clinical score of a multiple sclerosis model by transferring cells after selectively depleting Th17 cells with an anti-Embigin antibody into a mouse.

Figure 4 is a figure shows evaluation of an efficacy, on clinical score, of administration of, before onset of pathology, an anti-Embigin antibody to a mouse induced to make a multiple sclerosis model by immunizing with PLP.

PLP was mixed with Freund's complete adjuvant and subcutaneously immunized once. The anti-Embigin antibody (300 μg) was administered twice on days 7 and 14 (shown by arrows) after immunization. The clinical score was evaluated until day 18 after PLP immunization.