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Anti-FCGR1 immunotoxin H22 (scFv)-RTA (AGTO-G024R)

This immunotoxin was achieved by conjugating/fusing the Anti-FCGR1A scFv to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to acute myeloid leukemia (AML) cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of acute myeloid leukemia.      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Clone
H22
Molecule Class
scFv-RTA
Toxin Description
Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
acute myeloid leukemia
Target
Alternative Names
FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64); CD64; FCRI; CD64A; IGFR1; high affinity immunoglobulin gamma Fc receptor I; fcgammaRIa
Entrez Gene ID
2209
UniProt ID
P12314

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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