Anti-Human FXYD5 Recombinant Antibody (M53)
CAT#: TAB-261MZ
Recombinant monoclonal antibody to human dysadherin, M53, is a mouse monoclonal antibody intended for the prophylaxis and treatment of related disease.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10817/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human rectum
Immunohistochemical staining of human rectum shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10817/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10817/26170_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10817/26170_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10817/26170_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10817/26170_A_4_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10817/26170_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000089327-FXYD5
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Specifications
- Host Species
- Mouse
- Specificity
- Human
- Clone
- M53
- Applications
- Enzyme-linked Immunosorbent Assay
- Related Disease
- Non-small-cell lung cancer
Target
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Citations
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Juurikka, K., et al. "MMP8 increases tongue carcinoma cell-cell adhesion and diminishes migration via cleavage of anti-adhesive FXYD5." Oncogenesis 10.5 (2021): 44. https://doi.org/10.1038/s41389-021-00334-xThis research investigates the role of matrix metalloproteinase-8 (MMP8) in oral tongue squamous cell carcinoma (OTSCC), identifying a novel tumor-protective mechanism. The study demonstrates that MMP8 increases cell-cell adhesion and decreases cancer cell migration through the cleavage of FXYD domain-containing ion transport regulator 5 (FXYD5), an anti-adhesive glycoprotein. Using terminal amine isotopic labeling of substrates (TAILS) coupled with liquid chromatography and tandem mass spectrometry, researchers identified 36 potential substrates of MMP8, with FXYD5 being particularly significant. The cleavage of FXYD5 by MMP8 was confirmed through in vitro assays, and silencing FXYD5 increased cell-cell adhesion and diminished cell motility, similar to the effects of MMP8 overexpression.
Creative Biolabs provided a therapeutic antibody against FXYD5 (M53) that played a critical role in this research, enabling the investigators to target and study this anti-adhesive glycoprotein. As the study revealed FXYD5 as a marker of worse prognosis in OTSCC and other cancers, this antibody represents a promising therapeutic tool for further investigation. The researchers specifically highlighted the potential of the M53 antibody from Creative Biolabs as a candidate for future studies aimed at developing therapeutic approaches targeting FXYD5 in tongue cancer and potentially other cancer types where FXYD5 plays a similar role in promoting tumor progression.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "Clone M53"
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See other products for "FXYD5"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-261MZ-S(P) | Anti-Human FXYD5 Recombinant Antibody scFv Fragment (M53) | ELISA | |
| TAB-261MZ-F(E) | Anti-Human FXYD5 Recombinant Antibody Fab Fragment (M53) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY880 | Anti-FXYD5 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2684 | Anti-Human FXYD5 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC191 | Recombinant Anti-FXYD5 Vesicular Antibody, EV Displayed (VS-0425-YC191) | ELISA, FC, Cell-uptake |
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