Anti-FXYD5 (clone M53)-PEG-cardiac glycoside ADC (CAT#: ADC-110CL)

• Antibody Overview
• Anti-FXYD5 M53 Antibody,

• Clone
• M53

• Linker
• PEG (polyethylene glycol)

• Linker Class/Description
• Polyethylene glycol (PEG) is a polyether compound with many applications from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.

• Drug
• cardiac glycoside

• Drug Class/Description
• Cardiac glycosides are organic compounds containing a glycoside (sugar) that act on the contractile force of the cardiac muscle. Because of their potency in disrupting the function of the heart, most are extremely toxic. These glycosides are found as secondary metabolites in several plants, and in some insects, such as the milkweed butterflies, that consume the plants.
  Chemically, the aglycone [non-sugar] part of cardiac glycoside is a steroidal moiety.

• Introduction
• This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]

• Alternative Names
• FXYD5; FXYD domain containing ion transport regulator 5; RIC; IWU1; KCT1; OIT2; DYSAD; HSPC113; PRO6241; FXYD domain-containing ion transport regulator 5; dysadherin; keratinocytes associated transmembrane protein 1;

• Gene ID
• 53827

• UniProt ID
• Q96DB9

• TAB-261MZ
• Anti-Human FXYD5 Recombinant Antibody (M53)

• TAB-261MZ-S(P)
• Anti-Human FXYD5 Recombinant Antibody scFv Fragment (M53)

• TAB-261MZ-F(E)
• Anti-Human FXYD5 Recombinant Antibody Fab Fragment (M53)

• VS-1024-FY182
• Anti-FXYD5 (clone M53) Recombinant Antibody Coupled Liposome (VS-1024-FY182)

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