Anti-FXYD5 (clone M53) Recombinant Antibody Coupled Liposome (VS-1024-FY182) (CAT#: VS-1024-FY182)

• Potential Clinical Applications
• Melanoma

• Clone
• M53

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This recombinant mouse monoclonal antibody has been meticulously engineered to specifically bind to fibroblast growth factor 2 (FGF2). FGF2, also known as basic fibroblast growth factor (bFGF), plays a crucial role in various physiological processes, including cell proliferation, angiogenesis, and tissue repair. The development of this antibody involves sophisticated techniques to ensure high specificity and affinity for FGF2, enabling it to effectively interact with this growth factor in various biological contexts.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• FXYD5

• Introduction
• FXYD5 (also termed dysadherin or RIC) is a structurally and functionally unique member of the FXYD family. As other FXYD proteins, FXYD5 specifically interacts with the Na,K-ATPase and alters its kinetics by increasing Vmax However, unlike other family members FXYD5 appears to have additional functions, which cannot be readily explained by modulation of transport kinetics. Knockdown of FXYD5 in MDA-MB-231 breast cancer cells largely decreases expression and secretion of the chemokine CCL2 (MCP-1). A related effect has also been observed in renal cell carcinoma cells.

• Alternative Names
• FXYD5; FXYD domain containing ion transport regulator 5; RIC; IWU1; KCT1; OIT2; DYSAD; HSPC113; PRO6241; FXYD domain-containing ion transport regulator 5; dysadherin; keratinocytes associated transmembrane protein 1

• Full Name
• FXYD Domain Containing Ion Transport Regulator 5

• Gene ID
• 53827

• UniProt ID
• Q96DB9

• Sequence Similarities
• Belongs to the FXYD family.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Glycosylated. ( Q96DB9-FXYD5_HUMAN )
  Glycosylation at Ser127 ( NX_Q96DB9 [NX_Q96DB9-1] )
  Modification sites at PhosphoSitePlus ( Q96DB9 )
  Glycosylation from GlyGen (Q96DB9) 15 sites, 4 O-linked glycans

• Protein Refseq
• XP_047294897.1; XP_047294898.1; XP_047294899.1; XP_054177201.1; XP_054177202.1

• Function
• Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (By similarity).
  May increase NKA activity by increasing the apparent affinity for Na(+) (PubMed:18263667).
  Involved in down-regulation of E-cadherin which results in reduced cell adhesion.

• ADC-110CL
• Anti-FXYD5 (clone M53)-PEG-cardiac glycoside ADC

• TAB-261MZ
• Anti-Human FXYD5 Recombinant Antibody (M53)

• TAB-261MZ-S(P)
• Anti-Human FXYD5 Recombinant Antibody scFv Fragment (M53)

• TAB-261MZ-F(E)
• Anti-Human FXYD5 Recombinant Antibody Fab Fragment (M53)

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