Anti-GPA33 immunotoxin (scFv)-α-sar
CAT#: AGTO-G034F
This immunotoxin was achieved by conjugating/fusing the Anti-GPA33 scFv to α-sarcin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to GPA33 tumor antigen expressing cells. Once bind, alpha-Sarcin enters into the cells by receptor-mediated endocytosis and interacts with a single bond in the targeted ribosome and breaks it, causing the ribosome to be inactivated. It was designed for treatment of colon cancer.
Gene Expression
Normal Tissue
Figure 1 High expression in colon
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/ihc_selected.jpg
Normal Tissue
Figure 2 Low expression in liver
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/43100_A_7_4_val_selected.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/43100_A_9_3.jpg
Normal Tissue
Figure 4 Appendix
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes - Gradient Gradient: Ascending Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/43100_A_2_2.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143167-GPA33
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Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Molecule Class
- scFv-α-sar
- Toxin Description
- Alpha-Sarcin is a ribosome-inactivating protein produced in the mold Aspergillus giganteus. Specifically, alpha-sarcin cleaves the a portion of ribosomal RNA that forms the small ribosomal substrate. The high specificity of alpha-sarcin and its efficiency of cleavage are point of study and also account for this protein's very high toxicity level.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- colon cancer
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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|---|---|---|---|
| MOB-2119z | Mouse Anti-GPA33 Recombinant Antibody (MOB-2119z) | IHC, WB | Mouse IgG1 |
| HPAB-1717-FY | Human Anti-GPA33 Recombinant Antibody (clone 263A17) | ELISA | Human IgG |
| HPAB-1718-FY | Human Anti-GPA33 Recombinant Antibody (clone 125M10AA) | ELISA | Human IgG |
| HPAB-1719-FY | Human Anti-GPA33 Recombinant Antibody (clone 125M165DAAA) | ELISA | Human IgG |
| VS-0723-WK75 | Human Anti-GPA33 Recombinant Antibody (VS-0723-WK75) | FC | Chimeric (rabbit/human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2119z-F(E) | Recombinant Anti-Human GPA33 Antibody Fab Fragment | FC, WB, FuncS | Fab |
| HPAB-1717-FY-S(P) | Human Anti-GPA33 Recombinant Antibody (clone 263A17); Fab Fragment | ELISA | Human Fab |
| HPAB-0521-YJ-F(E) | Human Anti-GPA33 Recombinant Antibody; Fab Fragment (HPAB-0521-YJ-F(E)) | WB, IP, FC, ELISA, FuncS | Chimeric (Mouse/Human) Fab |
| HPAB-0522-YJ-F(E) | Human Anti-GPA33 Recombinant Antibody; Fab Fragment (HPAB-0522-YJ-F(E)) | WB, IP, FC, ELISA, FuncS | Humanized Fab |
| FAMAB-0161WJ-F(E) | Human Anti-GPA33 Recombinant Antibody (clone A2); Fab Fragment | ELISA, WB, FC, IF | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2119z-S(P) | Recombinant Anti-Human GPA33 Antibody scFv Fragment | WB, FC, FuncS | scFv |
| HPAB-1717-FY-F(E) | Human Anti-GPA33 Recombinant Antibody (clone 263A17); scFv Fragment | ELISA | Human scFv |
| HPAB-0521-YJ-S(P) | Human Anti-GPA33 Recombinant Antibody; scFv Fragment (HPAB-0521-YJ-S(P)) | WB, IP, FC, ELISA, FuncS | Human scFv |
| HPAB-0522-YJ-S(P) | Human Anti-GPA33 Recombinant Antibody; scFv Fragment (HPAB-0522-YJ-S(P)) | WB, IP, FC, ELISA, FuncS | Human scFv |
| FAMAB-0161WJ-S(P) | Human Anti-GPA33 Recombinant Antibody (clone A2); scFv Fragment | ELISA, WB, FC, IF | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1485 | Hi-Affi™ Rabbit Anti-GPA33 Recombinant Antibody (clone DS1485AB) | IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY112 | AbPlus™ Anti-GPA33 Magnetic Beads (VS-0424-XY112) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY194 | Human Anti-GPA33 scFv-Fc Chimera (VS-0325-FY194) | FC, Cyt, IHC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC555 | Recombinant Anti-GPA33 Vesicular Antibody, EV Displayed (VS-0425-YC555) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2878 | Anti-GPA33 Immunohistochemistry Kit | IHC |
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