Human Anti-GPA33 scFv-Fc Chimera (VS-0325-FY194) (CAT#: VS-0325-FY194)
This anti-GPA33 scFv-Fc antibody is a recombinant antibody fragment designed for the detection of colorectal cancer. It comprises a single-chain variable fragment (scFv) derived from a humanized antibody against GPA33, fused to the Fc region of human IgG1. This design provides enhanced tumor targeting and retention compared to smaller antibody fragments while maintaining advantages over full-sized antibodies in terms of tissue penetration and clearance.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 High expression in colon
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/ihc_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/ihc_selected.jpg
Figure 2 Low expression in liver
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/43100_A_7_4_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/43100_A_7_4_val_selected.jpg
Figure 3 Colon
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/43100_A_9_3.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/43100_A_9_3.jpg
Figure 4 Appendix
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes - Gradient Gradient: Ascending Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/43100_A_2_2.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes - Gradient Gradient: Ascending Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/43100_A_2_2.jpg
Figure 5 RNA cell line category: Cell line enriched (OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143167-GPA33
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143167-GPA33
Specifications
- Immunogen
- Human GPA33
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human GPA33
- Species Reactivity
- Human
- Applications
- Flow Cytometry, Cytotoxicity, Immunohistochemistry
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Glycoprotein A33; Glycoprotein A33 (Transmembrane); Transmembrane Glycoprotein A33; Cell Surface A33 Antigen; A33
- Gene ID
- 10223
- UniProt ID
- Q99795
- Long Name
- Glycoprotein A33
- Cellular Localization
- Membrane
- Post Translation Modifications
- N-glycosylated, contains approximately 8 kDa of N-linked carbohydrate.
Palmitoylated.
Glycosylation at Ser50, Asn112, Asn200, and Asn223
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 4 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_016855494.1; XP_047280436.1; XP_054189731.1; XP_054189732.1; NP_005805.1
- Function
- Human GPA33 is a cell surface glycoprotein expressed in the gastrointestinal tract and colorectal cancer. It serves as a target for monoclonal antibody-based cancer therapies.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2119z | Mouse Anti-GPA33 Recombinant Antibody (MOB-2119z) | IHC, WB | Mouse IgG1 |
| MOB-069LC | Rat Anti-GPA33 Recombinant Antibody (clone YC069) | ELISA, FC, WB | Rat IgG |
| HPAB-1717-FY | Human Anti-GPA33 Recombinant Antibody (clone 263A17) | ELISA | Human IgG |
| FAMAB-1151CQ | Human Anti-GPA33 Recombinant Antibody (clone huA33) | FC, Cyt, IHC | Human IgG1 |
| VS-0723-WK75 | Human Anti-GPA33 Recombinant Antibody (VS-0723-WK75) | FC | Chimeric (rabbit/human) IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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